Magnetic nano-particles and their applications in immunoassays

H. E. Horng, S. Y. Yang, Chin Yih Hong, H. C. Yang, S. H. Liao, C. M. Liu, C. C. Wu

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.

    Original languageEnglish
    Pages (from-to)999-1003
    Number of pages5
    JournalJournal of the Korean Physical Society
    Volume48
    Issue number5 I
    Publication statusPublished - 2006 May 1

      Fingerprint

    Keywords

    • Immunoassay
    • Magnetic nano-particles
    • SQUIDs

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

    Cite this

    Horng, H. E., Yang, S. Y., Hong, C. Y., Yang, H. C., Liao, S. H., Liu, C. M., & Wu, C. C. (2006). Magnetic nano-particles and their applications in immunoassays. Journal of the Korean Physical Society, 48(5 I), 999-1003.