Magnetic nano-particles and their applications in immunoassays

H. E. Horng, S. Y. Yang, Chin Yih Hong, H. C. Yang, S. H. Liao, C. M. Liu, C. C. Wu

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.

    Original languageEnglish
    Pages (from-to)999-1003
    Number of pages5
    JournalJournal of the Korean Physical Society
    Volume48
    Issue number5 I
    Publication statusPublished - 2006 May 1

    Fingerprint

    immunoassay
    magnetic signals
    magnetic relaxation
    delivery
    drugs
    coatings
    magnetization
    probes
    sensitivity
    sensors
    synthesis

    Keywords

    • Immunoassay
    • Magnetic nano-particles
    • SQUIDs

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

    Cite this

    Horng, H. E., Yang, S. Y., Hong, C. Y., Yang, H. C., Liao, S. H., Liu, C. M., & Wu, C. C. (2006). Magnetic nano-particles and their applications in immunoassays. Journal of the Korean Physical Society, 48(5 I), 999-1003.

    Magnetic nano-particles and their applications in immunoassays. / Horng, H. E.; Yang, S. Y.; Hong, Chin Yih; Yang, H. C.; Liao, S. H.; Liu, C. M.; Wu, C. C.

    In: Journal of the Korean Physical Society, Vol. 48, No. 5 I, 01.05.2006, p. 999-1003.

    Research output: Contribution to journalArticle

    Horng, HE, Yang, SY, Hong, CY, Yang, HC, Liao, SH, Liu, CM & Wu, CC 2006, 'Magnetic nano-particles and their applications in immunoassays', Journal of the Korean Physical Society, vol. 48, no. 5 I, pp. 999-1003.
    Horng, H. E. ; Yang, S. Y. ; Hong, Chin Yih ; Yang, H. C. ; Liao, S. H. ; Liu, C. M. ; Wu, C. C. / Magnetic nano-particles and their applications in immunoassays. In: Journal of the Korean Physical Society. 2006 ; Vol. 48, No. 5 I. pp. 999-1003.
    @article{da7bc238cf354a2f962a0160cbb67634,
    title = "Magnetic nano-particles and their applications in immunoassays",
    abstract = "Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.",
    keywords = "Immunoassay, Magnetic nano-particles, SQUIDs",
    author = "Horng, {H. E.} and Yang, {S. Y.} and Hong, {Chin Yih} and Yang, {H. C.} and Liao, {S. H.} and Liu, {C. M.} and Wu, {C. C.}",
    year = "2006",
    month = "5",
    day = "1",
    language = "English",
    volume = "48",
    pages = "999--1003",
    journal = "Journal of the Korean Physical Society",
    issn = "0374-4884",
    publisher = "Korean Physical Society",
    number = "5 I",

    }

    TY - JOUR

    T1 - Magnetic nano-particles and their applications in immunoassays

    AU - Horng, H. E.

    AU - Yang, S. Y.

    AU - Hong, Chin Yih

    AU - Yang, H. C.

    AU - Liao, S. H.

    AU - Liu, C. M.

    AU - Wu, C. C.

    PY - 2006/5/1

    Y1 - 2006/5/1

    N2 - Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.

    AB - Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.

    KW - Immunoassay

    KW - Magnetic nano-particles

    KW - SQUIDs

    UR - http://www.scopus.com/inward/record.url?scp=33745056508&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=33745056508&partnerID=8YFLogxK

    M3 - Article

    VL - 48

    SP - 999

    EP - 1003

    JO - Journal of the Korean Physical Society

    JF - Journal of the Korean Physical Society

    SN - 0374-4884

    IS - 5 I

    ER -