LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations

Yih Ru Wu; Louis C. Tan; Xiaoli Fu; Chiung Mei Chen; Wing Lok Au; Ling Chen; Yi Chun Chen; Kumar M. Prakash; Yifan Zheng; Guey Jen Lee-Chen; Yi Zhao; Jin Sheng Zeng; Eng King Tan; Zhong Pei

doi:10.1371/journal.pone.0036123

LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations

Yih Ru Wu, Louis C. Tan, Xiaoli Fu, Chiung Mei Chen, Wing Lok Au, Ling Chen, Yi Chun Chen, Kumar M. Prakash, Yifan Zheng, Guey Jen Lee-Chen, Yi Zhao, Jin Sheng Zeng, Eng King Tan, Zhong Pei

Department of Life Science

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.

Original language	English
Article number	e36123
Journal	PloS one
Volume	7
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0036123
Publication status	Published - 2012 Jul 10

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title = "LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations",

abstract = "It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.",

author = "Wu, {Yih Ru} and Tan, {Louis C.} and Xiaoli Fu and Chen, {Chiung Mei} and Au, {Wing Lok} and Ling Chen and Chen, {Yi Chun} and Prakash, {Kumar M.} and Yifan Zheng and Lee-Chen, {Guey Jen} and Yi Zhao and Zeng, {Jin Sheng} and Tan, {Eng King} and Zhong Pei",

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doi = "10.1371/journal.pone.0036123",

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T1 - LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations

AU - Wu, Yih Ru

AU - Tan, Louis C.

AU - Fu, Xiaoli

AU - Chen, Chiung Mei

AU - Au, Wing Lok

AU - Chen, Ling

AU - Chen, Yi Chun

AU - Prakash, Kumar M.

AU - Zheng, Yifan

AU - Lee-Chen, Guey Jen

AU - Zhao, Yi

AU - Zeng, Jin Sheng

AU - Tan, Eng King

AU - Pei, Zhong

PY - 2012/7/10

Y1 - 2012/7/10

N2 - It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.

AB - It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.

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ER -

LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations

Abstract

ASJC Scopus subject areas

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