LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations

Yih Ru Wu, Louis C. Tan, Xiaoli Fu, Chiung Mei Chen, Wing Lok Au, Ling Chen, Yi Chun Chen, Kumar M. Prakash, Yifan Zheng, Guey Jen Lee-Chen, Yi Zhao, Jin Sheng Zeng, Eng King Tan, Zhong Pei

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6 Citations (Scopus)

Abstract

It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.

Original languageEnglish
Article numbere36123
JournalPloS one
Volume7
Issue number7
DOIs
Publication statusPublished - 2012 Jul 10

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Wu, Y. R., Tan, L. C., Fu, X., Chen, C. M., Au, W. L., Chen, L., Chen, Y. C., Prakash, K. M., Zheng, Y., Lee-Chen, G. J., Zhao, Y., Zeng, J. S., Tan, E. K., & Pei, Z. (2012). LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations. PloS one, 7(7), [e36123]. https://doi.org/10.1371/journal.pone.0036123