Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detection

Kai Wen Huang; Shu Hsien Liao; Hong Chang Yang; Hsin Hsien Chen; Herng Er Horng; M. J. Chen; Shieh Yueh Yang

doi:10.1109/TASC.2010.2083617

Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detection

Kai Wen Huang^*, Shu Hsien Liao, Hong Chang Yang, Hsin Hsien Chen, Herng Er Horng, M. J. Chen, Shieh Yueh Yang

^*Corresponding author for this work

Undergraduate Program of Electro-Optical Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In this work, a study of hepatocellular carcinoma and normal livers in rats using nuclear magnetic resonance (NMR) based on superconducting quantum interference devices (SQUIDs) was presented. The time domain free induction decay signals,S_y(t) of cancerous liver tissue and control liver tissue of rats were measured to study the respective longitudinal relaxation rate T¹₁ The NMR data were fitted to [T-exp(-T _Bp/T₁ to derive the longitudinal relaxation times T ₁ for cancerous liver tissue and control liver tissue. It is found that T₁ cancer of cancerous liver tissues is 2.3 times higher than T₁ control of control liver tissues. Statistically the data suggest that T_1cancer T₁ control can be used to discriminate cancerous liver tissue from control tissue. Furthermore, differentiating cancerous tissues from control tissues was demonstrated using magnetic fluid phantoms as phantoms for cancerous and control tissues. The SQUID-detected NMR/MRI exhibits potential applications in clinical research.

Original language	English
Article number	5621873
Pages (from-to)	461-464
Number of pages	4
Journal	IEEE Transactions on Applied Superconductivity
Volume	21
Issue number	3 PART 1
DOIs	https://doi.org/10.1109/TASC.2010.2083617
Publication status	Published - 2011 Jun

Keywords

Flux coupling
Hepatocellular carcinoma (HCC)
Nmr
SQUID

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TASC.2010.2083617

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title = "Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detection",

abstract = "In this work, a study of hepatocellular carcinoma and normal livers in rats using nuclear magnetic resonance (NMR) based on superconducting quantum interference devices (SQUIDs) was presented. The time domain free induction decay signals,Sy(t) of cancerous liver tissue and control liver tissue of rats were measured to study the respective longitudinal relaxation rate T11 The NMR data were fitted to [T-exp(-T Bp/T1 to derive the longitudinal relaxation times T 1 for cancerous liver tissue and control liver tissue. It is found that T1 cancer of cancerous liver tissues is 2.3 times higher than T1 control of control liver tissues. Statistically the data suggest that T1cancer T1 control can be used to discriminate cancerous liver tissue from control tissue. Furthermore, differentiating cancerous tissues from control tissues was demonstrated using magnetic fluid phantoms as phantoms for cancerous and control tissues. The SQUID-detected NMR/MRI exhibits potential applications in clinical research.",

keywords = "Flux coupling, Hepatocellular carcinoma (HCC), Nmr, SQUID",

author = "Huang, {Kai Wen} and Liao, {Shu Hsien} and Yang, {Hong Chang} and Chen, {Hsin Hsien} and Horng, {Herng Er} and Chen, {M. J.} and Yang, {Shieh Yueh}",

note = "Funding Information: Manuscript received August 03, 2010; accepted September 26, 2010. Date of publication November 09, 2010; date of current version May 27, 2011. This work was supported by the National Science Council of Taiwan under Grant 98-2752-M-002-003-PAE.",

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doi = "10.1109/TASC.2010.2083617",

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AU - Huang, Kai Wen

AU - Liao, Shu Hsien

AU - Yang, Hong Chang

AU - Chen, Hsin Hsien

AU - Horng, Herng Er

AU - Chen, M. J.

AU - Yang, Shieh Yueh

N1 - Funding Information: Manuscript received August 03, 2010; accepted September 26, 2010. Date of publication November 09, 2010; date of current version May 27, 2011. This work was supported by the National Science Council of Taiwan under Grant 98-2752-M-002-003-PAE.

PY - 2011/6

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N2 - In this work, a study of hepatocellular carcinoma and normal livers in rats using nuclear magnetic resonance (NMR) based on superconducting quantum interference devices (SQUIDs) was presented. The time domain free induction decay signals,Sy(t) of cancerous liver tissue and control liver tissue of rats were measured to study the respective longitudinal relaxation rate T11 The NMR data were fitted to [T-exp(-T Bp/T1 to derive the longitudinal relaxation times T 1 for cancerous liver tissue and control liver tissue. It is found that T1 cancer of cancerous liver tissues is 2.3 times higher than T1 control of control liver tissues. Statistically the data suggest that T1cancer T1 control can be used to discriminate cancerous liver tissue from control tissue. Furthermore, differentiating cancerous tissues from control tissues was demonstrated using magnetic fluid phantoms as phantoms for cancerous and control tissues. The SQUID-detected NMR/MRI exhibits potential applications in clinical research.

AB - In this work, a study of hepatocellular carcinoma and normal livers in rats using nuclear magnetic resonance (NMR) based on superconducting quantum interference devices (SQUIDs) was presented. The time domain free induction decay signals,Sy(t) of cancerous liver tissue and control liver tissue of rats were measured to study the respective longitudinal relaxation rate T11 The NMR data were fitted to [T-exp(-T Bp/T1 to derive the longitudinal relaxation times T 1 for cancerous liver tissue and control liver tissue. It is found that T1 cancer of cancerous liver tissues is 2.3 times higher than T1 control of control liver tissues. Statistically the data suggest that T1cancer T1 control can be used to discriminate cancerous liver tissue from control tissue. Furthermore, differentiating cancerous tissues from control tissues was demonstrated using magnetic fluid phantoms as phantoms for cancerous and control tissues. The SQUID-detected NMR/MRI exhibits potential applications in clinical research.

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Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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