Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detection

Kai Wen Huang, Shu-Hsien Liao, Hong Chang Yang, Hsin Hsien Chen, Herng-Er Horng, M. J. Chen, Shieh Yueh Yang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this work, a study of hepatocellular carcinoma and normal livers in rats using nuclear magnetic resonance (NMR) based on superconducting quantum interference devices (SQUIDs) was presented. The time domain free induction decay signals,Sy(t) of cancerous liver tissue and control liver tissue of rats were measured to study the respective longitudinal relaxation rate T11 The NMR data were fitted to [T-exp(-T Bp/T1 to derive the longitudinal relaxation times T 1 for cancerous liver tissue and control liver tissue. It is found that T1 cancer of cancerous liver tissues is 2.3 times higher than T1 control of control liver tissues. Statistically the data suggest that T1cancer T1 control can be used to discriminate cancerous liver tissue from control tissue. Furthermore, differentiating cancerous tissues from control tissues was demonstrated using magnetic fluid phantoms as phantoms for cancerous and control tissues. The SQUID-detected NMR/MRI exhibits potential applications in clinical research.

Original languageEnglish
Article number5621873
Pages (from-to)461-464
Number of pages4
JournalIEEE Transactions on Applied Superconductivity
Volume21
Issue number3 PART 1
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

Magnetic resonance
magnetic resonance
Tumors
tumors
Nuclear magnetic resonance
liver
Tissue
Liver
Imaging techniques
nuclear magnetic resonance
SQUIDs
rats
Rats
cancer
interference
Magnetic fluids
Magnetic resonance imaging
Relaxation time
induction
relaxation time

Keywords

  • Flux coupling
  • Hepatocellular carcinoma (HCC)
  • Nmr
  • SQUID

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detection. / Huang, Kai Wen; Liao, Shu-Hsien; Yang, Hong Chang; Chen, Hsin Hsien; Horng, Herng-Er; Chen, M. J.; Yang, Shieh Yueh.

In: IEEE Transactions on Applied Superconductivity, Vol. 21, No. 3 PART 1, 5621873, 01.06.2011, p. 461-464.

Research output: Contribution to journalArticle

Huang, Kai Wen ; Liao, Shu-Hsien ; Yang, Hong Chang ; Chen, Hsin Hsien ; Horng, Herng-Er ; Chen, M. J. ; Yang, Shieh Yueh. / Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detection. In: IEEE Transactions on Applied Superconductivity. 2011 ; Vol. 21, No. 3 PART 1. pp. 461-464.
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