Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detection

Kai Wen Huang, Shu Hsien Liao, Hong Chang Yang, Hsin Hsien Chen, Herng Er Horng, M. J. Chen, Shieh Yueh Yang

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    In this work, a study of hepatocellular carcinoma and normal livers in rats using nuclear magnetic resonance (NMR) based on superconducting quantum interference devices (SQUIDs) was presented. The time domain free induction decay signals,Sy(t) of cancerous liver tissue and control liver tissue of rats were measured to study the respective longitudinal relaxation rate T11 The NMR data were fitted to [T-exp(-T Bp/T1 to derive the longitudinal relaxation times T 1 for cancerous liver tissue and control liver tissue. It is found that T1 cancer of cancerous liver tissues is 2.3 times higher than T1 control of control liver tissues. Statistically the data suggest that T1cancer T1 control can be used to discriminate cancerous liver tissue from control tissue. Furthermore, differentiating cancerous tissues from control tissues was demonstrated using magnetic fluid phantoms as phantoms for cancerous and control tissues. The SQUID-detected NMR/MRI exhibits potential applications in clinical research.

    Original languageEnglish
    Article number5621873
    Pages (from-to)461-464
    Number of pages4
    JournalIEEE Transactions on Applied Superconductivity
    Volume21
    Issue number3 PART 1
    DOIs
    Publication statusPublished - 2011 Jun 1

    Keywords

    • Flux coupling
    • Hepatocellular carcinoma (HCC)
    • Nmr
    • SQUID

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Electrical and Electronic Engineering

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