Abstract
An efficient iron(III) chloride catalyzed synthesis of highly substituted indolyltetrahydroquinoline derivatives from easily available starting materials, including indolylnitroalkenes, substituted anilines and various aldehydes is reported. The reaction utilized strong electron deficient dienophiles like indolylnitroalkene via a Povarov approach. The methodology shows good functional group tolerance and can be used to prepare fused indolo-benzonaphthyridine derivatives.
Original language | English |
---|---|
Pages (from-to) | 3849-3860 |
Number of pages | 12 |
Journal | Advanced Synthesis and Catalysis |
Volume | 356 |
Issue number | 18 |
DOIs | |
Publication status | Published - 2014 Dec 15 |
Keywords
- Indolo-benzonaphthyridine
- Indolylnitroalkene
- Indolyltetrahydro quinoline
- Iron(III) chloride
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry