Abstract
A simple and mild process was developed for the highly stereoselective synthesis of halogenated bicyclic [4.3.0] and [3.3.0] γ-lactams, possessing four stereocenters, from easily available cyclic 2-enynamides. The reaction required only an inexpensive iron(II) halide under dry air and was tolerant of aryl, heteroaryl, and alkyl groups at the alkyne terminus.
| Original language | English |
|---|---|
| Pages (from-to) | 2407-2410 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 18 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2016 May 20 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Yeh, M. C. P., Shiue, Y. S., Lin, H. H., Yu, T. Y., Hu, T. C., & Hong, J. J. (2016). Iron(II) Halide Promoted Cyclization of Cyclic 2-Enynamides: Stereoselective Synthesis of Halogenated Bicyclic γ-Lactams. Organic Letters, 18(10), 2407-2410. https://doi.org/10.1021/acs.orglett.6b00916