Abstract
A simple and mild process was developed for the highly stereoselective synthesis of halogenated bicyclic [4.3.0] and [3.3.0] γ-lactams, possessing four stereocenters, from easily available cyclic 2-enynamides. The reaction required only an inexpensive iron(II) halide under dry air and was tolerant of aryl, heteroaryl, and alkyl groups at the alkyne terminus.
Original language | English |
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Pages (from-to) | 2407-2410 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 18 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2016 May 20 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry