Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction

Veerababurao Kavala; Chunchi Lin; Chun Wei Kuo; Hulin Fang; Ching Fa Yao

doi:10.1016/j.tet.2011.11.022

Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction

Veerababurao Kavala, Chunchi Lin, Chun Wei Kuo, Hulin Fang, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives.

Original language	English
Pages (from-to)	1321-1329
Number of pages	9
Journal	Tetrahedron
Volume	68
Issue number	4
DOIs	https://doi.org/10.1016/j.tet.2011.11.022
Publication status	Published - 2012 Jan 28

Keywords

Flavanones
Iodine
Mannich reaction
Tetrahydropyrimidine

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2011.11.022

Cite this

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title = "Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction",

abstract = "A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives.",

keywords = "Flavanones, Iodine, Mannich reaction, Tetrahydropyrimidine",

author = "Veerababurao Kavala and Chunchi Lin and Kuo, {Chun Wei} and Hulin Fang and Yao, {Ching Fa}",

note = "Funding Information: We wish to express our sincere gratitude to the National Science Council of the Republic of China and National Taiwan Normal University ( 99T3030-2 and 99-D ) for providing financial support for the pursuit of this work. ",

year = "2012",

month = jan,

day = "28",

doi = "10.1016/j.tet.2011.11.022",

language = "English",

volume = "68",

pages = "1321--1329",

journal = "Tetrahedron",

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TY - JOUR

T1 - Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction

AU - Kavala, Veerababurao

AU - Lin, Chunchi

AU - Kuo, Chun Wei

AU - Fang, Hulin

AU - Yao, Ching Fa

N1 - Funding Information: We wish to express our sincere gratitude to the National Science Council of the Republic of China and National Taiwan Normal University ( 99T3030-2 and 99-D ) for providing financial support for the pursuit of this work.

PY - 2012/1/28

Y1 - 2012/1/28

N2 - A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives.

AB - A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives.

KW - Flavanones

KW - Iodine

KW - Mannich reaction

KW - Tetrahydropyrimidine

UR - http://www.scopus.com/inward/record.url?scp=84855421554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855421554&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2011.11.022

DO - 10.1016/j.tet.2011.11.022

M3 - Article

AN - SCOPUS:84855421554

SN - 0040-4020

VL - 68

SP - 1321

EP - 1329

JO - Tetrahedron

JF - Tetrahedron

IS - 4

ER -

Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction

Abstract

Keywords

ASJC Scopus subject areas

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CCDC 828379: Experimental Crystal Structure Determination

CCDC 828380: Experimental Crystal Structure Determination

Cite this

Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 828379: Experimental Crystal Structure Determination

CCDC 828380: Experimental Crystal Structure Determination

Cite this