Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction

Veerababurao Kavala; Chunchi Lin; Chun Wei Kuo; Hulin Fang; Ching Fa Yao

doi:10.1016/j.tet.2011.11.022

Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction

Veerababurao Kavala, Chunchi Lin, Chun Wei Kuo, Hulin Fang, Ching Fa Yao

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives.

Original language	English
Pages (from-to)	1321-1329
Number of pages	9
Journal	Tetrahedron
Volume	68
Issue number	4
DOIs	https://doi.org/10.1016/j.tet.2011.11.022
Publication status	Published - 2012 Jan 28

Keywords

Flavanones
Iodine
Mannich reaction
Tetrahydropyrimidine

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives.",

keywords = "Flavanones, Iodine, Mannich reaction, Tetrahydropyrimidine",

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AU - Kavala, Veerababurao

AU - Lin, Chunchi

AU - Kuo, Chun Wei

AU - Fang, Hulin

AU - Yao, Ching Fa

PY - 2012/1/28

Y1 - 2012/1/28

N2 - A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives.

AB - A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives.

KW - Flavanones

KW - Iodine

KW - Mannich reaction

KW - Tetrahydropyrimidine

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