Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition

Shijay Gao; Tingkai Tzeng; M. N.V. Sastry; Cheng Ming Chu; Ju Tsung Liu; Chunchi Lin; Ching Fa Yao

doi:10.1016/j.tetlet.2006.01.080

Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition

Shijay Gao, Tingkai Tzeng, M. N.V. Sastry, Cheng Ming Chu, Ju Tsung Liu, Chunchi Lin, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

We have described herein molecular iodine catalyzed Michael addition of thiol to α,β-unsaturated carboxylic acids. This environmentally benign catalytic system (iodine) used under mild and solvent-free conditions to achieve the corresponding adducts in excellent yield.

Original language	English
Pages (from-to)	1889-1893
Number of pages	5
Journal	Tetrahedron Letters
Volume	47
Issue number	12
DOIs	https://doi.org/10.1016/j.tetlet.2006.01.080
Publication status	Published - 2006 Mar 20

Keywords

Conjugate addition
Iodine
Solvent free
Thiols
α,β-Unsaturated carboxylic acid

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2006.01.080

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title = "Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition",

abstract = "We have described herein molecular iodine catalyzed Michael addition of thiol to α,β-unsaturated carboxylic acids. This environmentally benign catalytic system (iodine) used under mild and solvent-free conditions to achieve the corresponding adducts in excellent yield.",

keywords = "Conjugate addition, Iodine, Solvent free, Thiols, α,β-Unsaturated carboxylic acid",

author = "Shijay Gao and Tingkai Tzeng and Sastry, {M. N.V.} and Chu, {Cheng Ming} and Liu, {Ju Tsung} and Chunchi Lin and Yao, {Ching Fa}",

note = "Funding Information: Financial support of this work by the National Taiwan Normal University (ORD93–C) and National Science Council of the Republic of China is gratefully acknowledged. ",

year = "2006",

month = mar,

day = "20",

doi = "10.1016/j.tetlet.2006.01.080",

language = "English",

volume = "47",

pages = "1889--1893",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition

AU - Gao, Shijay

AU - Tzeng, Tingkai

AU - Sastry, M. N.V.

AU - Chu, Cheng Ming

AU - Liu, Ju Tsung

AU - Lin, Chunchi

AU - Yao, Ching Fa

N1 - Funding Information: Financial support of this work by the National Taiwan Normal University (ORD93–C) and National Science Council of the Republic of China is gratefully acknowledged.

PY - 2006/3/20

Y1 - 2006/3/20

N2 - We have described herein molecular iodine catalyzed Michael addition of thiol to α,β-unsaturated carboxylic acids. This environmentally benign catalytic system (iodine) used under mild and solvent-free conditions to achieve the corresponding adducts in excellent yield.

AB - We have described herein molecular iodine catalyzed Michael addition of thiol to α,β-unsaturated carboxylic acids. This environmentally benign catalytic system (iodine) used under mild and solvent-free conditions to achieve the corresponding adducts in excellent yield.

KW - Conjugate addition

KW - Iodine

KW - Solvent free

KW - Thiols

KW - α,β-Unsaturated carboxylic acid

UR - http://www.scopus.com/inward/record.url?scp=32644478985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32644478985&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2006.01.080

DO - 10.1016/j.tetlet.2006.01.080

M3 - Article

AN - SCOPUS:32644478985

SN - 0040-4039

VL - 47

SP - 1889

EP - 1893

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 12

ER -

Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition

Abstract

Keywords

ASJC Scopus subject areas

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