Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition

Shijay Gao, Tingkai Tzeng, M. N.V. Sastry, Cheng Ming Chu, Ju Tsung Liu, Chunchi Lin, Ching-Fa Yao

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We have described herein molecular iodine catalyzed Michael addition of thiol to α,β-unsaturated carboxylic acids. This environmentally benign catalytic system (iodine) used under mild and solvent-free conditions to achieve the corresponding adducts in excellent yield.

Original languageEnglish
Pages (from-to)1889-1893
Number of pages5
JournalTetrahedron Letters
Issue number12
Publication statusPublished - 2006 Mar 20



  • Conjugate addition
  • Iodine
  • Solvent free
  • Thiols
  • α,β-Unsaturated carboxylic acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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