Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition

Shijay Gao, Tingkai Tzeng, M. N.V. Sastry, Cheng Ming Chu, Ju Tsung Liu, Chunchi Lin, Ching-Fa Yao

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We have described herein molecular iodine catalyzed Michael addition of thiol to α,β-unsaturated carboxylic acids. This environmentally benign catalytic system (iodine) used under mild and solvent-free conditions to achieve the corresponding adducts in excellent yield.

Original languageEnglish
Pages (from-to)1889-1893
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number12
DOIs
Publication statusPublished - 2006 Mar 20

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Carboxylic Acids
Sulfhydryl Compounds
Iodine

Keywords

  • Conjugate addition
  • Iodine
  • Solvent free
  • Thiols
  • α,β-Unsaturated carboxylic acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition. / Gao, Shijay; Tzeng, Tingkai; Sastry, M. N.V.; Chu, Cheng Ming; Liu, Ju Tsung; Lin, Chunchi; Yao, Ching-Fa.

In: Tetrahedron Letters, Vol. 47, No. 12, 20.03.2006, p. 1889-1893.

Research output: Contribution to journalArticle

Gao, Shijay ; Tzeng, Tingkai ; Sastry, M. N.V. ; Chu, Cheng Ming ; Liu, Ju Tsung ; Lin, Chunchi ; Yao, Ching-Fa. / Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition. In: Tetrahedron Letters. 2006 ; Vol. 47, No. 12. pp. 1889-1893.
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AU - Liu, Ju Tsung

AU - Lin, Chunchi

AU - Yao, Ching-Fa

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