Intramolecular 1,3-dipolar cycloaddition of cyclo-1,3-diene- and -1,3,5-triene-tethered nitrile oxides gave tricyclic isoxazolines as a single stereoisomer in most cases. The relative stereochemistry of tricycle-fused isoxazolines resulting from 1,3-dipolar cycloaddition of cyclo-1,3-diene- tethered nitrile oxides is cis-cis, whereas from cyclohepta-1,3,5-triene- tethered nitrile oxides the cis-trans isomer predominates.
- Cyclohexa- and cyclohepta-1,3-dienes
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry