Interrupting Prolonged Sitting with Intermittent Walking Increases Postprandial Gut Hormone Responses

Yung Chih Chen, Jean Philippe Walhin, Aaron Hengist, Javier T. Gonzalez, James A. Betts, Dylan Thompson

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Introduction Continuous exercise can increase postprandial gut hormone such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) responses, but it is unknown whether interrupting prolonged sitting with intermittent walking elicits this effect. Method Ten participants with central overweight/obesity (7 men and 3 postmenopausal women, 51 ± 5 yr; mean ± SD) completed a randomized crossover study in which they consumed breakfast and lunch in the laboratory while either sitting continuously for the entire 5.5-h period (SIT) or the prolonged sitting interrupted every 20 min by walking briskly (6.4 km·h-1) for 2 min (BREAKS). Blood samples were collected at regular intervals to examine postprandial plasma GLP-1, PYY, and glucose-dependent insulinotropic polypeptide concentrations. Adipose tissue samples were collected at baseline and at the end of the trials to examine changes in net dipeptidyl peptidase 4 secretion from primary explants. Results Mean (95% confidence interval) postprandial GLP-1 and PYY incremental area under curve values were elevated by 26% and 31% in the BREAKS trial versus SIT (8.4 [0.7, 16.1] vs 6.7 [-0.8, 14.2], P = 0.001, and 26.9 [8.1, 45.6] vs 20.4 [5.1, 35.8] nmol·330 min·L-1, P = 0.024, respectively) but without any such effect on glucose-dependent insulinotropic polypeptide (P = 0.076) or net adipose tissue dipeptidyl peptidase 4 secretion (P > 0.05). Conclusions Interrupting prolonged sitting with regular short bouts of brisk walking increases postprandial GLP-1 and PYY concentrations in healthy middle-age men and women with central adiposity.

Original languageEnglish
Pages (from-to)1183-1189
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume54
Issue number7
DOIs
Publication statusPublished - 2022 Jul 1

Keywords

  • GLUCAGON-LIKE PEPTIDE 1
  • GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE
  • INCRETIN
  • PEPTIDE YY
  • PROLONGED SITTING
  • SEDENTARY

ASJC Scopus subject areas

  • Medicine(all)

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