Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan

Y. R. Wu; C. M. Chen; J. C. Hwang; S. T. Chen; I. H. Feng; H. C. Hsu; C. N. Liu; Y. T. Liu; Y. Y. Lai; H. J. Huang; G. J. Lee-Chen

doi:10.1007/s00702-007-0726-4

Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan

Y. R. Wu, C. M. Chen, J. C. Hwang, S. T. Chen, I. H. Feng, H. C. Hsu, C. N. Liu, Y. T. Liu, Y. Y. Lai, H. J. Huang, G. J. Lee-Chen^*

^*Corresponding author for this work

Department of Life Science

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1α C-889T and IL-1β C-511T polymorphisms with the risk of PD. No significant difference in the genotype distribution of the analyzed polymorphisms was found between PD and controls. However, after stratification by age, individuals over 70 years of age carrying IL-1α-889 C/T genotype demonstrated a significant decrease in risk of developing PD (OR = 0.44; 95% CI = 0.22-0.88, p = 0.021) and the decrease is strengthened by IL-1β-511 T-carrying genotype (OR = 0.28; 95% CI = 0.11-0.71, p = 0.008). Our data suggest that IL-1α, acting synergistically with IL-1β, plays role in PD susceptibility among Taiwanese people older than 70 years of age.

Original language	English
Pages (from-to)	1173-1177
Number of pages	5
Journal	Journal of Neural Transmission
Volume	114
Issue number	9
DOIs	https://doi.org/10.1007/s00702-007-0726-4
Publication status	Published - 2007 Sept

Keywords

Disease association
Interleukin 1
Parkinson's disease
Promoter SNP

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00702-007-0726-4

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title = "Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan",

abstract = "Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1α C-889T and IL-1β C-511T polymorphisms with the risk of PD. No significant difference in the genotype distribution of the analyzed polymorphisms was found between PD and controls. However, after stratification by age, individuals over 70 years of age carrying IL-1α-889 C/T genotype demonstrated a significant decrease in risk of developing PD (OR = 0.44; 95% CI = 0.22-0.88, p = 0.021) and the decrease is strengthened by IL-1β-511 T-carrying genotype (OR = 0.28; 95% CI = 0.11-0.71, p = 0.008). Our data suggest that IL-1α, acting synergistically with IL-1β, plays role in PD susceptibility among Taiwanese people older than 70 years of age.",

keywords = "Disease association, Interleukin 1, Parkinson's disease, Promoter SNP",

author = "Wu, {Y. R.} and Chen, {C. M.} and Hwang, {J. C.} and Chen, {S. T.} and Feng, {I. H.} and Hsu, {H. C.} and Liu, {C. N.} and Liu, {Y. T.} and Lai, {Y. Y.} and Huang, {H. J.} and Lee-Chen, {G. J.}",

year = "2007",

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doi = "10.1007/s00702-007-0726-4",

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AU - Wu, Y. R.

AU - Chen, C. M.

AU - Hwang, J. C.

AU - Chen, S. T.

AU - Feng, I. H.

AU - Hsu, H. C.

AU - Liu, C. N.

AU - Liu, Y. T.

AU - Lai, Y. Y.

AU - Huang, H. J.

AU - Lee-Chen, G. J.

PY - 2007/9

Y1 - 2007/9

N2 - Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1α C-889T and IL-1β C-511T polymorphisms with the risk of PD. No significant difference in the genotype distribution of the analyzed polymorphisms was found between PD and controls. However, after stratification by age, individuals over 70 years of age carrying IL-1α-889 C/T genotype demonstrated a significant decrease in risk of developing PD (OR = 0.44; 95% CI = 0.22-0.88, p = 0.021) and the decrease is strengthened by IL-1β-511 T-carrying genotype (OR = 0.28; 95% CI = 0.11-0.71, p = 0.008). Our data suggest that IL-1α, acting synergistically with IL-1β, plays role in PD susceptibility among Taiwanese people older than 70 years of age.

AB - Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1α C-889T and IL-1β C-511T polymorphisms with the risk of PD. No significant difference in the genotype distribution of the analyzed polymorphisms was found between PD and controls. However, after stratification by age, individuals over 70 years of age carrying IL-1α-889 C/T genotype demonstrated a significant decrease in risk of developing PD (OR = 0.44; 95% CI = 0.22-0.88, p = 0.021) and the decrease is strengthened by IL-1β-511 T-carrying genotype (OR = 0.28; 95% CI = 0.11-0.71, p = 0.008). Our data suggest that IL-1α, acting synergistically with IL-1β, plays role in PD susceptibility among Taiwanese people older than 70 years of age.

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KW - Parkinson's disease

KW - Promoter SNP

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Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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