Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan

Y. R. Wu, C. M. Chen, Ji-Chuu Hwang, S. T. Chen, I. H. Feng, H. C. Hsu, C. N. Liu, Y. T. Liu, Y. Y. Lai, H. J. Huang, Guey-Jen Lee

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Abstract

Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1α C-889T and IL-1β C-511T polymorphisms with the risk of PD. No significant difference in the genotype distribution of the analyzed polymorphisms was found between PD and controls. However, after stratification by age, individuals over 70 years of age carrying IL-1α-889 C/T genotype demonstrated a significant decrease in risk of developing PD (OR = 0.44; 95% CI = 0.22-0.88, p = 0.021) and the decrease is strengthened by IL-1β-511 T-carrying genotype (OR = 0.28; 95% CI = 0.11-0.71, p = 0.008). Our data suggest that IL-1α, acting synergistically with IL-1β, plays role in PD susceptibility among Taiwanese people older than 70 years of age.

Original languageEnglish
Pages (from-to)1173-1177
Number of pages5
JournalJournal of Neural Transmission
Volume114
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

Fingerprint

Parkinson disease
interleukins
polymorphism
interleukin-1
Taiwan
Polymorphism
Interleukin-1
Parkinson Disease
genotype
Genotype
pathogenesis
neuroprotective effect
Disease Susceptibility
Neuroprotective Agents
stratification
case-control studies
disease resistance
Case-Control Studies
magnetic permeability

Keywords

  • Disease association
  • Interleukin 1
  • Parkinson's disease
  • Promoter SNP

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan. / Wu, Y. R.; Chen, C. M.; Hwang, Ji-Chuu; Chen, S. T.; Feng, I. H.; Hsu, H. C.; Liu, C. N.; Liu, Y. T.; Lai, Y. Y.; Huang, H. J.; Lee, Guey-Jen.

In: Journal of Neural Transmission, Vol. 114, No. 9, 01.09.2007, p. 1173-1177.

Research output: Contribution to journalArticle

Wu, YR, Chen, CM, Hwang, J-C, Chen, ST, Feng, IH, Hsu, HC, Liu, CN, Liu, YT, Lai, YY, Huang, HJ & Lee, G-J 2007, 'Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan', Journal of Neural Transmission, vol. 114, no. 9, pp. 1173-1177. https://doi.org/10.1007/s00702-007-0726-4
Wu, Y. R. ; Chen, C. M. ; Hwang, Ji-Chuu ; Chen, S. T. ; Feng, I. H. ; Hsu, H. C. ; Liu, C. N. ; Liu, Y. T. ; Lai, Y. Y. ; Huang, H. J. ; Lee, Guey-Jen. / Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan. In: Journal of Neural Transmission. 2007 ; Vol. 114, No. 9. pp. 1173-1177.
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