Interleukin-1α and -1β promoter polymorphisms in Taiwanese patients with dementia

Hsiu Kuan Wang, Wen Chuin Hsu, Hon Chung Fung, Jun Cheng Lin, Hai Pei Hsu, Yih Ru Wu, Yu-Ying Hsu, Fen Ju Hu, Guey-Jen Lee, Chiung Mei Chen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1α -889 C/T and IL-1β -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). Methods: AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method. Results: No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1α -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1α -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1β -511T-carrying genotype slightly strengthens the negative association of the IL-1α -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024). Conclusion: Our data suggest a protective role of the IL-1α -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.

Original languageEnglish
Pages (from-to)104-110
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume24
Issue number2
DOIs
Publication statusPublished - 2007 Jul 1

Fingerprint

Vascular Dementia
Interleukin-1
Dementia
Genotype
Alzheimer Disease
Odds Ratio
National Institute of Neurological Disorders and Stroke
Confidence Intervals
Neuroprotective Agents
Single Nucleotide Polymorphism
Multivariate Analysis

Keywords

  • Alzheimer's disease
  • Interleukin-1
  • Promoter single nucleotide polymorphism
  • Vascular dementia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Wang, H. K., Hsu, W. C., Fung, H. C., Lin, J. C., Hsu, H. P., Wu, Y. R., ... Chen, C. M. (2007). Interleukin-1α and -1β promoter polymorphisms in Taiwanese patients with dementia. Dementia and Geriatric Cognitive Disorders, 24(2), 104-110. https://doi.org/10.1159/000104829

Interleukin-1α and -1β promoter polymorphisms in Taiwanese patients with dementia. / Wang, Hsiu Kuan; Hsu, Wen Chuin; Fung, Hon Chung; Lin, Jun Cheng; Hsu, Hai Pei; Wu, Yih Ru; Hsu, Yu-Ying; Hu, Fen Ju; Lee, Guey-Jen; Chen, Chiung Mei.

In: Dementia and Geriatric Cognitive Disorders, Vol. 24, No. 2, 01.07.2007, p. 104-110.

Research output: Contribution to journalArticle

Wang, Hsiu Kuan ; Hsu, Wen Chuin ; Fung, Hon Chung ; Lin, Jun Cheng ; Hsu, Hai Pei ; Wu, Yih Ru ; Hsu, Yu-Ying ; Hu, Fen Ju ; Lee, Guey-Jen ; Chen, Chiung Mei. / Interleukin-1α and -1β promoter polymorphisms in Taiwanese patients with dementia. In: Dementia and Geriatric Cognitive Disorders. 2007 ; Vol. 24, No. 2. pp. 104-110.
@article{22b584314c5f43f7b913c70521e62f24,
title = "Interleukin-1α and -1β promoter polymorphisms in Taiwanese patients with dementia",
abstract = "Background: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1α -889 C/T and IL-1β -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). Methods: AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method. Results: No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1α -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9{\%}, p = 0.036) andtheIL-1α -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95{\%} confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1β -511T-carrying genotype slightly strengthens the negative association of the IL-1α -889 CT genotype with VaD (odds ratio: 0.26; 95{\%} confidence interval: 0.08-0.79, p = 0.024). Conclusion: Our data suggest a protective role of the IL-1α -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.",
keywords = "Alzheimer's disease, Interleukin-1, Promoter single nucleotide polymorphism, Vascular dementia",
author = "Wang, {Hsiu Kuan} and Hsu, {Wen Chuin} and Fung, {Hon Chung} and Lin, {Jun Cheng} and Hsu, {Hai Pei} and Wu, {Yih Ru} and Yu-Ying Hsu and Hu, {Fen Ju} and Guey-Jen Lee and Chen, {Chiung Mei}",
year = "2007",
month = "7",
day = "1",
doi = "10.1159/000104829",
language = "English",
volume = "24",
pages = "104--110",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Interleukin-1α and -1β promoter polymorphisms in Taiwanese patients with dementia

AU - Wang, Hsiu Kuan

AU - Hsu, Wen Chuin

AU - Fung, Hon Chung

AU - Lin, Jun Cheng

AU - Hsu, Hai Pei

AU - Wu, Yih Ru

AU - Hsu, Yu-Ying

AU - Hu, Fen Ju

AU - Lee, Guey-Jen

AU - Chen, Chiung Mei

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Background: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1α -889 C/T and IL-1β -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). Methods: AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method. Results: No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1α -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1α -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1β -511T-carrying genotype slightly strengthens the negative association of the IL-1α -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024). Conclusion: Our data suggest a protective role of the IL-1α -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.

AB - Background: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1α -889 C/T and IL-1β -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). Methods: AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method. Results: No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1α -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1α -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1β -511T-carrying genotype slightly strengthens the negative association of the IL-1α -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024). Conclusion: Our data suggest a protective role of the IL-1α -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.

KW - Alzheimer's disease

KW - Interleukin-1

KW - Promoter single nucleotide polymorphism

KW - Vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=34447626071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447626071&partnerID=8YFLogxK

U2 - 10.1159/000104829

DO - 10.1159/000104829

M3 - Article

VL - 24

SP - 104

EP - 110

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 2

ER -