Interleukin-1α and -1β promoter polymorphisms in Taiwanese patients with dementia

Hsiu Kuan Wang, Wen Chuin Hsu, Hon Chung Fung, Jun Cheng Lin, Hai Pei Hsu, Yih Ru Wu, Yuying Hsu, Fen Ju Hu, Guey Jen Lee-Chen, Chiung Mei Chen

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Abstract

Background: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1α -889 C/T and IL-1β -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). Methods: AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method. Results: No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1α -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1α -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1β -511T-carrying genotype slightly strengthens the negative association of the IL-1α -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024). Conclusion: Our data suggest a protective role of the IL-1α -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.

Original languageEnglish
Pages (from-to)104-110
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume24
Issue number2
DOIs
Publication statusPublished - 2007 Jul 1

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Keywords

  • Alzheimer's disease
  • Interleukin-1
  • Promoter single nucleotide polymorphism
  • Vascular dementia

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

Cite this

Wang, H. K., Hsu, W. C., Fung, H. C., Lin, J. C., Hsu, H. P., Wu, Y. R., Hsu, Y., Hu, F. J., Lee-Chen, G. J., & Chen, C. M. (2007). Interleukin-1α and -1β promoter polymorphisms in Taiwanese patients with dementia. Dementia and Geriatric Cognitive Disorders, 24(2), 104-110. https://doi.org/10.1159/000104829