The development of artificial intelligence has revolutionized impact on education. Cramming education will no longer exist, and students have to learn more than memorizing. Secondly, artificial intelligence can provide a variety of effective learning methods, not only students can record learning content, but also make learning more effective. Teachers can also analyze the students’ learning and get feedback from the students so that they can learn from each other. STEAM education is increasingly valued by many countries, such as the ITEEA’s Education by Design, 6E Learning by DeSIGN STEM courses, and NASA-sponsored robot STEAM courses. South Korea have further promoted STEAM education (such as Incheon University) to propose the Wheel Model (STEAM & HUG). STEAM’s goals combining with design thinking, cross-domain learning, and teamwork form the main spirits of Taiwan’s 12-year national curriculum, which are “taking the initiative, engaging the public, and seeking the common good”. Those main components of artificial intelligence are knowledge reasoning, planning, machine learning, natural language processing, computer vision, and robotics. Artificial intelligence becomes an important learning and educational tool for students. Meanwhile, students learn through artificial intelligence products. Based on artificial intelligence components and STEAM education, how to develop instruction model and learning modules will be a most important theme. Through effectiveness artificial intelligence STEAM instruction, students’ higher-order thinking ability, creativity, problem solving ability, and the literacy of artificial intelligence will be improved effectively.