Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight

The influence of a proprietary blend of modified cellulose and cetylated fatty acids (Trisynex™, Imagenetix, Inc., San Diego, CA 92127, USA) on adipocytokine and regional body composition responses to a weight loss program was examined. Twenty-two women (Supplement group (S) (n = 11): age = 36.8 ± 7.2 years; weight = 87.1 ± 6.2 kg; % body fat = 43.4 ± 4.1; Placebo group (P) (n = 11): age = 38.3 ± 6.8 years; weight = 86.9 ± 4.7 kg; % body fat = 44.3 ± 2.0) completed an 8-week placebo-controlled, double-blind study consisting of a caloric restricted diet and cardiovascular exercise. Body composition and serum insulin, leptin, and adiponectin were assessed at pre-, mid-, and post-intervention. From pre- to post-intervention, significant decreases (P < 0.05) were observed for body weight (S: 87.1 ± 6.2-77.9 ± 5.1 kg; P: 86.9 ± 4.7-82.7 ± 3.8 kg) (P < 0.05 S vs. P), % body fat (S: 43.4 ± 4.1-36.1 ± 3.6; P: 44.3 ± 2.0-40.6 ± 1.2) (P < 0.05 S vs. P), leptin (S: 28.3 ± 3.5-16.2 ± 2.6 ng ml^-1; P: 29.4 ± 3.2-19.9 ± 1.1 ng ml^-1) (P < 0.05 S vs. P), and insulin (S: 7.3 ± 0.8-5.1 ± 0.2 mU l^-1; P: 7.7 ± 0.9-5.1 ± 0.3 mU l^-1). Serum adiponectin increased (P < 0.05) (S: 12.2 ± 2.4-26.3 ± 3.0 μg ml^-1: 12.6 ± 2.0-21.8 ± 3.1 μg ml^-1) (P < 0.05 for S vs. P). Supplementation with a proprietary blend of modified cellulose and cetylated fatty acids during an 8-week weight loss program exhibited favorable effects on adipocytokines and regional body composition.