Abstract
Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population. This exploratory study examined the relationship of single-nucleotide polymorphism (SNP) variations in the genes encoding the NMDA receptor (i.e., GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) with emotion and social behavior in adolescents. For this study, 832 tenth-grade Taiwanese volunteers were recruited, and their scores from the Beck Youth Inventories were used to evaluate their emotional and social impairments. Based on these scores, GRIN1 (rs4880213) was significantly associated with depression and disruptive behavior. In addition, GRIN2B (rs7301328) was significantly associated with disruptive behavior. Because emotional and social impairment greatly influence learning ability, the findings of this study provide important information for clinical treatment and the development of promising prevention and treatment strategies, especially in the area of psychological adjustment.
| Original language | English |
|---|---|
| Article number | 6851592 |
| Journal | Neural Plasticity |
| Volume | 2016 |
| DOIs | |
| Publication status | Published - 2016 Jan 1 |
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ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Influence of genetic variants of the N-methyl-D-aspartate receptor on emotion and social behavior in adolescents. / Lee, Li Ching; Cho, Ying Chun; Lin, Pei Jung; Yeh, Ting Chi; Chang, Chun Yen; Yeh, Ting Kuang.
In: Neural Plasticity, Vol. 2016, 6851592, 01.01.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of genetic variants of the N-methyl-D-aspartate receptor on emotion and social behavior in adolescents
AU - Lee, Li Ching
AU - Cho, Ying Chun
AU - Lin, Pei Jung
AU - Yeh, Ting Chi
AU - Chang, Chun Yen
AU - Yeh, Ting Kuang
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population. This exploratory study examined the relationship of single-nucleotide polymorphism (SNP) variations in the genes encoding the NMDA receptor (i.e., GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) with emotion and social behavior in adolescents. For this study, 832 tenth-grade Taiwanese volunteers were recruited, and their scores from the Beck Youth Inventories were used to evaluate their emotional and social impairments. Based on these scores, GRIN1 (rs4880213) was significantly associated with depression and disruptive behavior. In addition, GRIN2B (rs7301328) was significantly associated with disruptive behavior. Because emotional and social impairment greatly influence learning ability, the findings of this study provide important information for clinical treatment and the development of promising prevention and treatment strategies, especially in the area of psychological adjustment.
AB - Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population. This exploratory study examined the relationship of single-nucleotide polymorphism (SNP) variations in the genes encoding the NMDA receptor (i.e., GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) with emotion and social behavior in adolescents. For this study, 832 tenth-grade Taiwanese volunteers were recruited, and their scores from the Beck Youth Inventories were used to evaluate their emotional and social impairments. Based on these scores, GRIN1 (rs4880213) was significantly associated with depression and disruptive behavior. In addition, GRIN2B (rs7301328) was significantly associated with disruptive behavior. Because emotional and social impairment greatly influence learning ability, the findings of this study provide important information for clinical treatment and the development of promising prevention and treatment strategies, especially in the area of psychological adjustment.
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UR - http://www.scopus.com/inward/citedby.url?scp=84954549670&partnerID=8YFLogxK
U2 - 10.1155/2016/6851592
DO - 10.1155/2016/6851592
M3 - Article
C2 - 26819771
AN - SCOPUS:84954549670
VL - 2016
JO - Neural Plasticity
JF - Neural Plasticity
SN - 2090-5904
M1 - 6851592
ER -