Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

S. Y. Yang, C. B. Lan, C. H. Chen, H. E. Horng*, Chin Yih Hong, H. C. Yang, Y. K. Lai, Y. H. Lin, K. S. Teng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

Original languageEnglish
Pages (from-to)3266-3269
Number of pages4
JournalJournal of Magnetism and Magnetic Materials
Issue number19
Publication statusPublished - 2009 Oct


  • Hemoglobin
  • Immunomagnetic reduction
  • Magnetic nanoparticle

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics


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