Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

Shieh-Yueh Yang; C. B. Lan; C. H. Chen; Herng-Er Horng; Chin Yih Hong; Hong-Chang Yang; Y. K. Lai; Y. H. Lin; K. S. Teng

doi:10.1016/j.jmmm.2009.05.075

Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

Shieh-Yueh Yang, C. B. Lan, C. H. Chen, Herng-Er Horng, Chin Yih Hong, Hong-Chang Yang, Y. K. Lai, Y. H. Lin, K. S. Teng

Graduate Institute of Electro-Optical Science And Technology

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

Original language	English
Pages (from-to)	3266-3269
Number of pages	4
Journal	Journal of Magnetism and Magnetic Materials
Volume	321
Issue number	19
DOIs	https://doi.org/10.1016/j.jmmm.2009.05.075
Publication status	Published - 2009 Oct 1

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Keywords

Hemoglobin
Immunomagnetic reduction
Magnetic nanoparticle

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics

Cite this

Yang, S-Y., Lan, C. B., Chen, C. H., Horng, H-E., Hong, C. Y., Yang, H-C., Lai, Y. K., Lin, Y. H., & Teng, K. S. (2009). Independency of Fe ions in hemoglobin on immunomagnetic reduction assay. Journal of Magnetism and Magnetic Materials, 321(19), 3266-3269. https://doi.org/10.1016/j.jmmm.2009.05.075

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abstract = "Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.",

keywords = "Hemoglobin, Immunomagnetic reduction, Magnetic nanoparticle",

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AU - Yang, Shieh-Yueh

AU - Lan, C. B.

AU - Chen, C. H.

AU - Horng, Herng-Er

AU - Hong, Chin Yih

AU - Yang, Hong-Chang

AU - Lai, Y. K.

AU - Lin, Y. H.

AU - Teng, K. S.

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AB - Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

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KW - Immunomagnetic reduction

KW - Magnetic nanoparticle

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10.1016/j.jmmm.2009.05.075