Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

Shieh-Yueh Yang, C. B. Lan, C. H. Chen, Herng-Er Horng, Chin Yih Hong, Hong-Chang Yang, Y. K. Lai, Y. H. Lin, K. S. Teng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

Original languageEnglish
Pages (from-to)3266-3269
Number of pages4
JournalJournal of Magnetism and Magnetic Materials
Volume321
Issue number19
DOIs
Publication statusPublished - 2009 Oct 1

Keywords

  • Hemoglobin
  • Immunomagnetic reduction
  • Magnetic nanoparticle

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Independency of Fe ions in hemoglobin on immunomagnetic reduction assay'. Together they form a unique fingerprint.

  • Cite this

    Yang, S-Y., Lan, C. B., Chen, C. H., Horng, H-E., Hong, C. Y., Yang, H-C., Lai, Y. K., Lin, Y. H., & Teng, K. S. (2009). Independency of Fe ions in hemoglobin on immunomagnetic reduction assay. Journal of Magnetism and Magnetic Materials, 321(19), 3266-3269. https://doi.org/10.1016/j.jmmm.2009.05.075