Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

Shieh-Yueh Yang, C. B. Lan, C. H. Chen, Herng-Er Horng, Chin Yih Hong, Hong-Chang Yang, Y. K. Lai, Y. H. Lin, K. S. Teng

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

    Original languageEnglish
    Pages (from-to)3266-3269
    Number of pages4
    JournalJournal of Magnetism and Magnetic Materials
    Volume321
    Issue number19
    DOIs
    Publication statusPublished - 2009 Oct 1

    Keywords

    • Hemoglobin
    • Immunomagnetic reduction
    • Magnetic nanoparticle

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics

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