Abstract
Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.
| Original language | English |
|---|---|
| Pages (from-to) | 3266-3269 |
| Number of pages | 4 |
| Journal | Journal of Magnetism and Magnetic Materials |
| Volume | 321 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2009 Oct 1 |
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Keywords
- Hemoglobin
- Immunomagnetic reduction
- Magnetic nanoparticle
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
Cite this
Independency of Fe ions in hemoglobin on immunomagnetic reduction assay. / Yang, Shieh-Yueh; Lan, C. B.; Chen, C. H.; Horng, Herng-Er; Hong, Chin Yih; Yang, Hong-Chang; Lai, Y. K.; Lin, Y. H.; Teng, K. S.
In: Journal of Magnetism and Magnetic Materials, Vol. 321, No. 19, 01.10.2009, p. 3266-3269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Independency of Fe ions in hemoglobin on immunomagnetic reduction assay
AU - Yang, Shieh-Yueh
AU - Lan, C. B.
AU - Chen, C. H.
AU - Horng, Herng-Er
AU - Hong, Chin Yih
AU - Yang, Hong-Chang
AU - Lai, Y. K.
AU - Lin, Y. H.
AU - Teng, K. S.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.
AB - Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.
KW - Hemoglobin
KW - Immunomagnetic reduction
KW - Magnetic nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=67650099781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650099781&partnerID=8YFLogxK
U2 - 10.1016/j.jmmm.2009.05.075
DO - 10.1016/j.jmmm.2009.05.075
M3 - Article
AN - SCOPUS:67650099781
VL - 321
SP - 3266
EP - 3269
JO - Journal of Magnetism and Magnetic Materials
JF - Journal of Magnetism and Magnetic Materials
SN - 0304-8853
IS - 19
ER -