Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system

Chung Lan Kao, Shih Hwa Chiou, Yann Jang Chen, Sher Singh, Han Tso Lin, Ren Shyan Liu, Chih Wen Lo, Chi Chang Yang, Chin Wen Chi, Chen Hsen Lee, Tai Tong Wong

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The atypical teratoid/rhabdoid tumor, primary to the central nervous system, is a highly malignant and aggressive neoplasm of infancy and childhood. Although having distinct biological features and clinical outcomes, it is frequently misdiagnosed as primitive neuroectodermal tumor/medulloblastoma. To further distinguish the underlying pathogenesis and to identify biological markers for clinical use, an atypical teratoid/rhabdoid tumor-derived cell line was established and its gene expression pattern analyzed in comparison to the human astrocyte SVG12 cell line and the human DAOY medulloblastoma cell line using a complementary DNA microarray method. The osteopontin gene was found specifically upregulated in atypical teratoid/rhabdoid tumor cells. This specificity was confirmed by immunohistochemistry in pathological sections of tissues from atypical teratoid/rhabdoid tumor patients. Even though the role of osteopontin in the cytopathogenesis of atypical teratoid/rhabdoid tumor still needs to be determined, our data support that overexpressed osteopontin is a potential diagnostic marker for atypical teratoid/rhabdoid tumor.

Original languageEnglish
Pages (from-to)769-778
Number of pages10
JournalModern Pathology
Volume18
Issue number6
DOIs
Publication statusPublished - 2005 Jun 1

Keywords

  • Atypical teratoid/rhabdoid tumor
  • Medulloblastoma
  • Microarray
  • Osteopontin
  • Real-time RT-PCR

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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