TY - JOUR
T1 - In vivo and real-time measurement of magnetic nanoparticles distribution in animals by scanning SQUID biosusceptometry for biomedicine study
AU - Chieh, J. J.
AU - Tseng, W. K.
AU - Horng, H. E.
AU - Hong, C. Y.
AU - Yang, H. C.
AU - Wu, C. C.
N1 - Funding Information:
Manuscript received June 30, 2010; revised September 14, 2010; accepted October 12, 2010. Date of publication October 28, 2010; date of current version September 21, 2011. This work was supported by the National Science Council of Taiwan under Grant 98-2323-B-003-001-CC2, Grant 98-2112-M-003-003, Grant 98-221-E-003-001-MY2, and Grant 98-2752-M-002-016-PAE, and by the Ministry of Economic Affairs under Grant 1Z970688_SBIR_ and Grant S09800226-203_JAID_, and by the Department of Health under Grant DOH98-TD-N-111-008 and Grant 99G0012. Asterisk indicates corresponding author.
PY - 2011/10
Y1 - 2011/10
N2 - Magnetic nanoparticles have been widely applied to biomagnetism, such as drug deliver, magnetic labeling, and contrast agent for in vivo image, etc. To localize the distribution of these magnetic particles in living organism is the first important issue to confirm the effects of magnetic nanoparticles and also evaluate the possible untoward effects. In this study, a scanning high T c rf-SQUID superconducting quantum interference devices (SQUIDs) biosusceptometry, composed of static SQUID unit and scanning coil sets, is developed for biomedicine study with the advantages of easy operation and unshielded environment. The characteristics tests showed that the system had the low noise of 8 pT/Hz at 400 Hz and the high sensitivity with the minimum detectable magnetization around 4.5 × 10 -3 EMU at distance of 13 mm. A magnetic nanoparticle detection test, performed by ex vivo scanning of the magnetic fluids filled capillary under swine skin for simulation of blood vessels in living bodies, confirmed that the system is feasible for dynamic tracking of magnetic nanoparticles. Based on this result, we performed further studies in rats to clarify the dynamic distribution of magnetic nanoparticle in living organism for the pharmacokinetics analysis like drug delivers, and propose the possible physiological metabolism of intravenous magnetic nanoparticles.
AB - Magnetic nanoparticles have been widely applied to biomagnetism, such as drug deliver, magnetic labeling, and contrast agent for in vivo image, etc. To localize the distribution of these magnetic particles in living organism is the first important issue to confirm the effects of magnetic nanoparticles and also evaluate the possible untoward effects. In this study, a scanning high T c rf-SQUID superconducting quantum interference devices (SQUIDs) biosusceptometry, composed of static SQUID unit and scanning coil sets, is developed for biomedicine study with the advantages of easy operation and unshielded environment. The characteristics tests showed that the system had the low noise of 8 pT/Hz at 400 Hz and the high sensitivity with the minimum detectable magnetization around 4.5 × 10 -3 EMU at distance of 13 mm. A magnetic nanoparticle detection test, performed by ex vivo scanning of the magnetic fluids filled capillary under swine skin for simulation of blood vessels in living bodies, confirmed that the system is feasible for dynamic tracking of magnetic nanoparticles. Based on this result, we performed further studies in rats to clarify the dynamic distribution of magnetic nanoparticle in living organism for the pharmacokinetics analysis like drug delivers, and propose the possible physiological metabolism of intravenous magnetic nanoparticles.
KW - In vivo
KW - magnetic particle image
KW - pharmacokinetics
KW - superconducting quantum interference device (SQUID)
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U2 - 10.1109/TBME.2010.2090042
DO - 10.1109/TBME.2010.2090042
M3 - Article
C2 - 21041154
AN - SCOPUS:80053191822
SN - 0018-9294
VL - 58
SP - 2719
EP - 2724
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 10 PART 1
M1 - 5613158
ER -