In-vivo and fast examination of iron concentration of magnetic nano-particles in an animal torso via scanning SQUID biosusceptometry

W. K. Tseng; J. J. Chieh; S. Y. Yang; H. E. Horng; C. Y. Hong; H. C. Yang; C. C. Wu

doi:10.1109/TASC.2011.2107871

In-vivo and fast examination of iron concentration of magnetic nano-particles in an animal torso via scanning SQUID biosusceptometry

W. K. Tseng, J. J. Chieh, S. Y. Yang, H. E. Horng, C. Y. Hong, H. C. Yang, C. C. Wu

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

To determine the iron concentration of administrated magnetic nano-particles in animals is essential for evaluation of arrival efficiency in target regions in biomagnetism studies. In this work, a high T_c superconucting quantum interference devices (SQUID) biosusceptometry with a scanning coil set is developed. The measurement principal is based on the AC susceptibility of magnetic nano-particles, and the low noise of 8 pT/√Hz at 400 Hz is characterized in unshielded environment. The dextran-coated magnetic nano-particle of 50 nm in diameter is administrated intravenously into Wistar male rats to demonstrate the in-vivo and fast examination feasibility of this instrument. The in-vivo results of heart region and liver region explained the reasonable biological phenomenon of magnetic nano-particles in animals. Good correlation of concentration-time curve between the induction-coupled-plasma (ICP) and in-vivo examination by AC susceptibility measurement in rat liver region until 4 hours after injection of magnetic naoparticle validates the in-vivo measurement of iron concentration. After 4 hrs post magnetic nanoparticle injection, the phagocyted magnetic nano-particles in liver tissue shows antiferromagnetism properties and explain the difference between the low in-vivo intensity by AC susceptibility measurement and high intensity by ICP.

Original language	English
Article number	5721748
Pages (from-to)	2250-2253
Number of pages	4
Journal	IEEE Transactions on Applied Superconductivity
Volume	21
Issue number	3 PART 2
DOIs	https://doi.org/10.1109/TASC.2011.2107871
Publication status	Published - 2011 Jun

Keywords

Antiferromagnetism
In-vivo
Magnetic nano-particle
SQUID

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

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10.1109/TASC.2011.2107871

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title = "In-vivo and fast examination of iron concentration of magnetic nano-particles in an animal torso via scanning SQUID biosusceptometry",

abstract = "To determine the iron concentration of administrated magnetic nano-particles in animals is essential for evaluation of arrival efficiency in target regions in biomagnetism studies. In this work, a high Tc superconucting quantum interference devices (SQUID) biosusceptometry with a scanning coil set is developed. The measurement principal is based on the AC susceptibility of magnetic nano-particles, and the low noise of 8 pT/√Hz at 400 Hz is characterized in unshielded environment. The dextran-coated magnetic nano-particle of 50 nm in diameter is administrated intravenously into Wistar male rats to demonstrate the in-vivo and fast examination feasibility of this instrument. The in-vivo results of heart region and liver region explained the reasonable biological phenomenon of magnetic nano-particles in animals. Good correlation of concentration-time curve between the induction-coupled-plasma (ICP) and in-vivo examination by AC susceptibility measurement in rat liver region until 4 hours after injection of magnetic naoparticle validates the in-vivo measurement of iron concentration. After 4 hrs post magnetic nanoparticle injection, the phagocyted magnetic nano-particles in liver tissue shows antiferromagnetism properties and explain the difference between the low in-vivo intensity by AC susceptibility measurement and high intensity by ICP.",

keywords = "Antiferromagnetism, In-vivo, Magnetic nano-particle, SQUID",

author = "Tseng, {W. K.} and Chieh, {J. J.} and Yang, {S. Y.} and Horng, {H. E.} and Hong, {C. Y.} and Yang, {H. C.} and Wu, {C. C.}",

note = "Funding Information: Manuscript received August 02, 2010; accepted January 14, 2011. Date of publication February 28, 2011; date of current version May 27, 2011. This work was supported by the National Science Council of Taiwan under Grants 98-2323-B-003-001-CC2, 98-2112-M-003-003, 98-221-E-003-001-MY2, and 98-2323-B-003-001-CC2, and Ministry of Economic Affairs under Grants 1Z970688-SBIR and S09800226-203-JAID, and Department of Health under Grants DOH98-TD-N-111-008 and 99G0012.",

year = "2011",

month = jun,

doi = "10.1109/TASC.2011.2107871",

language = "English",

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T1 - In-vivo and fast examination of iron concentration of magnetic nano-particles in an animal torso via scanning SQUID biosusceptometry

AU - Tseng, W. K.

AU - Chieh, J. J.

AU - Yang, S. Y.

AU - Horng, H. E.

AU - Hong, C. Y.

AU - Yang, H. C.

AU - Wu, C. C.

N1 - Funding Information: Manuscript received August 02, 2010; accepted January 14, 2011. Date of publication February 28, 2011; date of current version May 27, 2011. This work was supported by the National Science Council of Taiwan under Grants 98-2323-B-003-001-CC2, 98-2112-M-003-003, 98-221-E-003-001-MY2, and 98-2323-B-003-001-CC2, and Ministry of Economic Affairs under Grants 1Z970688-SBIR and S09800226-203-JAID, and Department of Health under Grants DOH98-TD-N-111-008 and 99G0012.

PY - 2011/6

Y1 - 2011/6

N2 - To determine the iron concentration of administrated magnetic nano-particles in animals is essential for evaluation of arrival efficiency in target regions in biomagnetism studies. In this work, a high Tc superconucting quantum interference devices (SQUID) biosusceptometry with a scanning coil set is developed. The measurement principal is based on the AC susceptibility of magnetic nano-particles, and the low noise of 8 pT/√Hz at 400 Hz is characterized in unshielded environment. The dextran-coated magnetic nano-particle of 50 nm in diameter is administrated intravenously into Wistar male rats to demonstrate the in-vivo and fast examination feasibility of this instrument. The in-vivo results of heart region and liver region explained the reasonable biological phenomenon of magnetic nano-particles in animals. Good correlation of concentration-time curve between the induction-coupled-plasma (ICP) and in-vivo examination by AC susceptibility measurement in rat liver region until 4 hours after injection of magnetic naoparticle validates the in-vivo measurement of iron concentration. After 4 hrs post magnetic nanoparticle injection, the phagocyted magnetic nano-particles in liver tissue shows antiferromagnetism properties and explain the difference between the low in-vivo intensity by AC susceptibility measurement and high intensity by ICP.

AB - To determine the iron concentration of administrated magnetic nano-particles in animals is essential for evaluation of arrival efficiency in target regions in biomagnetism studies. In this work, a high Tc superconucting quantum interference devices (SQUID) biosusceptometry with a scanning coil set is developed. The measurement principal is based on the AC susceptibility of magnetic nano-particles, and the low noise of 8 pT/√Hz at 400 Hz is characterized in unshielded environment. The dextran-coated magnetic nano-particle of 50 nm in diameter is administrated intravenously into Wistar male rats to demonstrate the in-vivo and fast examination feasibility of this instrument. The in-vivo results of heart region and liver region explained the reasonable biological phenomenon of magnetic nano-particles in animals. Good correlation of concentration-time curve between the induction-coupled-plasma (ICP) and in-vivo examination by AC susceptibility measurement in rat liver region until 4 hours after injection of magnetic naoparticle validates the in-vivo measurement of iron concentration. After 4 hrs post magnetic nanoparticle injection, the phagocyted magnetic nano-particles in liver tissue shows antiferromagnetism properties and explain the difference between the low in-vivo intensity by AC susceptibility measurement and high intensity by ICP.

KW - Antiferromagnetism

KW - In-vivo

KW - Magnetic nano-particle

KW - SQUID

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JO - IEEE Transactions on Applied Superconductivity

JF - IEEE Transactions on Applied Superconductivity

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In-vivo and fast examination of iron concentration of magnetic nano-particles in an animal torso via scanning SQUID biosusceptometry

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Keywords

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