In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

Chin Yih Hong; Shieh Yueh Yang; K. W. Huang; Herng Er Horng; Hong Chang Yang

doi:10.1115/DETC2011-47178

In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

Chin Yih Hong^*
, Shieh Yueh Yang
, K. W. Huang
, Herng Er Horng
, Hong Chang Yang

^*Corresponding author for this work

Institute and Undergraduate Program of Electro-Optical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.

Original language	English
Title of host publication	ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
Pages	11-15
Number of pages	5
DOIs	https://doi.org/10.1115/DETC2011-47178
Publication status	Published - 2011
Event	ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 - Washington, DC, United States Duration: 2011 Aug 28 → 2011 Aug 31

Publication series

Name	Proceedings of the ASME Design Engineering Technical Conference
Volume	7

Conference

Conference	ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
Country/Territory	United States
City	Washington, DC
Period	2011/08/28 → 2011/08/31

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carcinoembryonic antigen
Colorectal carcinoma
Enzyme-linked immunosorbent assay
Immunomagnetic reduction

ASJC Scopus subject areas

Modelling and Simulation
Mechanical Engineering
Computer Science Applications
Computer Graphics and Computer-Aided Design

Access to Document

10.1115/DETC2011-47178

Cite this

Hong, C. Y., Yang, S. Y., Huang, K. W., Horng, H. E., & Yang, H. C. (2011). In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 (pp. 11-15). (Proceedings of the ASME Design Engineering Technical Conference; Vol. 7). https://doi.org/10.1115/DETC2011-47178

In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. / Hong, Chin Yih; Yang, Shieh Yueh; Huang, K. W. et al.
ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011. 2011. p. 11-15 (Proceedings of the ASME Design Engineering Technical Conference; Vol. 7).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hong, CY, Yang, SY, Huang, KW, Horng, HE & Yang, HC 2011, In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. in ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011. Proceedings of the ASME Design Engineering Technical Conference, vol. 7, pp. 11-15, ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011, Washington, DC, United States, 2011/08/28. https://doi.org/10.1115/DETC2011-47178

Hong CY, Yang SY, Huang KW, Horng HE, Yang HC. In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011. 2011. p. 11-15. (Proceedings of the ASME Design Engineering Technical Conference). doi: 10.1115/DETC2011-47178

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title = "In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles",

abstract = "The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.",

keywords = "Carcinoembryonic antigen, Colorectal carcinoma, Enzyme-linked immunosorbent assay, Immunomagnetic reduction",

author = "Hong, \{Chin Yih\} and Yang, \{Shieh Yueh\} and Huang, \{K. W.\} and Horng, \{Herng Er\} and Yang, \{Hong Chang\}",

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AU - Hong, Chin Yih

AU - Yang, Shieh Yueh

AU - Huang, K. W.

AU - Horng, Herng Er

AU - Yang, Hong Chang

PY - 2011

Y1 - 2011

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AB - The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.

KW - Carcinoembryonic antigen

KW - Colorectal carcinoma

KW - Enzyme-linked immunosorbent assay

KW - Immunomagnetic reduction

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In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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