In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles

Chin Yih Hong, Shieh-Yueh Yang, K. W. Huang, Herng-Er Horng, Hong-Chang Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.

Original languageEnglish
Title of host publicationASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
Pages11-15
Number of pages5
DOIs
Publication statusPublished - 2011 Dec 1
EventASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 - Washington, DC, United States
Duration: 2011 Aug 282011 Aug 31

Publication series

NameProceedings of the ASME Design Engineering Technical Conference
Volume7

Other

OtherASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
CountryUnited States
CityWashington, DC
Period11/8/2811/8/31

Keywords

  • Carcinoembryonic antigen
  • Colorectal carcinoma
  • Enzyme-linked immunosorbent assay
  • Immunomagnetic reduction

ASJC Scopus subject areas

  • Modelling and Simulation
  • Mechanical Engineering
  • Computer Science Applications
  • Computer Graphics and Computer-Aided Design

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  • Cite this

    Hong, C. Y., Yang, S-Y., Huang, K. W., Horng, H-E., & Yang, H-C. (2011). In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles. In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 (pp. 11-15). (Proceedings of the ASME Design Engineering Technical Conference; Vol. 7). https://doi.org/10.1115/DETC2011-47178