In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes

Tsung Hsien Tsai; Tzung Hsun Tsai; Wen Huey Wu; Jonathon Te Peng Tseng; Po Jung Tsai

doi:10.1016/j.foodchem.2009.07.062

In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes

Tsung Hsien Tsai, Tzung Hsun Tsai, Wen Huey Wu, Jonathon Te Peng Tseng, Po Jung Tsai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Propionibacterium acnes play an important role in the pathogenesis of acne by inducing certain inflammatory mediators and comedogenesis. The objective of this study was to evaluate the antimicrobial and anti-inflammatory effects of herbal extracts against P. acnes. Among the ten tested herbs, methanolic extracts of rose (Rosa damascene), duzhong (Eucommia ulmoides Oliv.), and yerba mate (Ilex paraguariensis) were found to inhibit the growth of P. acnes with respective minimum inhibitory concentrations of 2, 0.5, and 1 mg/ml. In addition, duzhong and yerba mate extracts reduced the secretion of pro-inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-8, and IL-1β by human monocytic THP-1 cells pretreated with heat-killed P. acnes at a concentration of 0.1 mg/ml. Our results suggested that duzhong and yerba mate extracts possess both antimicrobial and anti-inflammatory effects against P. acnes and can possibly be used as therapeutic agents for acne.

Original language	English
Pages (from-to)	964-968
Number of pages	5
Journal	Food Chemistry
Volume	119
Issue number	3
DOIs	https://doi.org/10.1016/j.foodchem.2009.07.062
Publication status	Published - 2010 Apr 1

Keywords

Anti-inflammation
Cytokines
Herbs
Propionibacterium acnes

ASJC Scopus subject areas

Analytical Chemistry
Food Science

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10.1016/j.foodchem.2009.07.062

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title = "In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes",

abstract = "Propionibacterium acnes play an important role in the pathogenesis of acne by inducing certain inflammatory mediators and comedogenesis. The objective of this study was to evaluate the antimicrobial and anti-inflammatory effects of herbal extracts against P. acnes. Among the ten tested herbs, methanolic extracts of rose (Rosa damascene), duzhong (Eucommia ulmoides Oliv.), and yerba mate (Ilex paraguariensis) were found to inhibit the growth of P. acnes with respective minimum inhibitory concentrations of 2, 0.5, and 1 mg/ml. In addition, duzhong and yerba mate extracts reduced the secretion of pro-inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-8, and IL-1β by human monocytic THP-1 cells pretreated with heat-killed P. acnes at a concentration of 0.1 mg/ml. Our results suggested that duzhong and yerba mate extracts possess both antimicrobial and anti-inflammatory effects against P. acnes and can possibly be used as therapeutic agents for acne.",

keywords = "Anti-inflammation, Cytokines, Herbs, Propionibacterium acnes",

author = "Tsai, {Tsung Hsien} and Tsai, {Tzung Hsun} and Wu, {Wen Huey} and Tseng, {Jonathon Te Peng} and Tsai, {Po Jung}",

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AU - Tsai, Tsung Hsien

AU - Tsai, Tzung Hsun

AU - Wu, Wen Huey

AU - Tseng, Jonathon Te Peng

AU - Tsai, Po Jung

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Propionibacterium acnes play an important role in the pathogenesis of acne by inducing certain inflammatory mediators and comedogenesis. The objective of this study was to evaluate the antimicrobial and anti-inflammatory effects of herbal extracts against P. acnes. Among the ten tested herbs, methanolic extracts of rose (Rosa damascene), duzhong (Eucommia ulmoides Oliv.), and yerba mate (Ilex paraguariensis) were found to inhibit the growth of P. acnes with respective minimum inhibitory concentrations of 2, 0.5, and 1 mg/ml. In addition, duzhong and yerba mate extracts reduced the secretion of pro-inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-8, and IL-1β by human monocytic THP-1 cells pretreated with heat-killed P. acnes at a concentration of 0.1 mg/ml. Our results suggested that duzhong and yerba mate extracts possess both antimicrobial and anti-inflammatory effects against P. acnes and can possibly be used as therapeutic agents for acne.

AB - Propionibacterium acnes play an important role in the pathogenesis of acne by inducing certain inflammatory mediators and comedogenesis. The objective of this study was to evaluate the antimicrobial and anti-inflammatory effects of herbal extracts against P. acnes. Among the ten tested herbs, methanolic extracts of rose (Rosa damascene), duzhong (Eucommia ulmoides Oliv.), and yerba mate (Ilex paraguariensis) were found to inhibit the growth of P. acnes with respective minimum inhibitory concentrations of 2, 0.5, and 1 mg/ml. In addition, duzhong and yerba mate extracts reduced the secretion of pro-inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-8, and IL-1β by human monocytic THP-1 cells pretreated with heat-killed P. acnes at a concentration of 0.1 mg/ml. Our results suggested that duzhong and yerba mate extracts possess both antimicrobial and anti-inflammatory effects against P. acnes and can possibly be used as therapeutic agents for acne.

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KW - Cytokines

KW - Herbs

KW - Propionibacterium acnes

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In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes

Abstract

Keywords

ASJC Scopus subject areas

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