In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes

Tsung Hsien Tsai, Tzung Hsun Tsai, Wen Huey Wu, Jonathon Te Peng Tseng, Po Jung Tsai

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Propionibacterium acnes play an important role in the pathogenesis of acne by inducing certain inflammatory mediators and comedogenesis. The objective of this study was to evaluate the antimicrobial and anti-inflammatory effects of herbal extracts against P. acnes. Among the ten tested herbs, methanolic extracts of rose (Rosa damascene), duzhong (Eucommia ulmoides Oliv.), and yerba mate (Ilex paraguariensis) were found to inhibit the growth of P. acnes with respective minimum inhibitory concentrations of 2, 0.5, and 1 mg/ml. In addition, duzhong and yerba mate extracts reduced the secretion of pro-inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-8, and IL-1β by human monocytic THP-1 cells pretreated with heat-killed P. acnes at a concentration of 0.1 mg/ml. Our results suggested that duzhong and yerba mate extracts possess both antimicrobial and anti-inflammatory effects against P. acnes and can possibly be used as therapeutic agents for acne.

Original languageEnglish
Pages (from-to)964-968
Number of pages5
JournalFood Chemistry
Volume119
Issue number3
DOIs
Publication statusPublished - 2010 Apr 1

Fingerprint

Propionibacterium acnes
Ilex paraguariensis
anti-inflammatory activity
yerba mate
herbs
Anti-Inflammatory Agents
anti-infective agents
acne
Interleukin-8
Interleukin-1
Acne Vulgaris
extracts
Tumor Necrosis Factor-alpha
Cytokines
Eucommiaceae
Rosa
Eucommia ulmoides
tumor necrosis factors
interleukin-8
interleukin-1

Keywords

  • Anti-inflammation
  • Cytokines
  • Herbs
  • Propionibacterium acnes

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

Cite this

In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes. / Tsai, Tsung Hsien; Tsai, Tzung Hsun; Wu, Wen Huey; Tseng, Jonathon Te Peng; Tsai, Po Jung.

In: Food Chemistry, Vol. 119, No. 3, 01.04.2010, p. 964-968.

Research output: Contribution to journalArticle

Tsai, Tsung Hsien ; Tsai, Tzung Hsun ; Wu, Wen Huey ; Tseng, Jonathon Te Peng ; Tsai, Po Jung. / In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes. In: Food Chemistry. 2010 ; Vol. 119, No. 3. pp. 964-968.
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