Impaired frontal synchronization of spontaneous magnetoencephalographic activity in patients with bipolar disorder

Shyan-Shiou Chen, Pei Chi Tu, Tung Ping Su, Jen Chuen Hsieh, Ying Chia Lin, Li Fen Chen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Recent functional imaging studies demonstrated that brain exhibit coherent, synchronized activities during resting state and the dynamics may be impaired in various psychiatric illnesses. In order to investigate the change of neural dynamics in bipolar disorder, we used a new nonlinear measurement "similarity index" to analyze the magnetoencephalography (MEG) recordings and test the hypothesis that there are synchronization changes within different frequency bands in the frontal cortex of patients with bipolar disorder. Ten patients with bipolar I disorder during euthymic phase and ten normal controls underwent 2 min eye-closed resting recording with a whole-head 306-channel MEG system. Eleven channels of MEG data from frontal area were selected for analysis. Synchronization level in the delta (2-4 Hz), theta (4-8 Hz), alpha (8-12 Hz) and beta (12-24 Hz) bands was calculated for each subject and compared across group. The results showed that significant dynamic changes in bipolar patients can be characterized by increased synchronization of slow frequency oscillations (delta) and decreased synchronization of fast frequency oscillations (beta). Furthermore, the positive correlation between beta synchronization level and preservative errors in Wisconcin card sorting task was found which would implicate the deficit of executive function in bipolar patients. Our findings indicate that analysis of spontaneous MEG recordings at resting state using nonlinear dynamic approaches may disclose the subtle regional changes of neural dynamics in BD.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalNeuroscience Letters
Volume445
Issue number2
DOIs
Publication statusPublished - 2008 Nov 14

Fingerprint

Magnetoencephalography
Bipolar Disorder
Nonlinear Dynamics
Executive Function
Frontal Lobe
Psychiatry
Head
Brain

Keywords

  • Bipolar disorders
  • Magnetoencephalography
  • Nonlinear dynamics
  • Similarity index
  • Synchronization

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Impaired frontal synchronization of spontaneous magnetoencephalographic activity in patients with bipolar disorder. / Chen, Shyan-Shiou; Tu, Pei Chi; Su, Tung Ping; Hsieh, Jen Chuen; Lin, Ying Chia; Chen, Li Fen.

In: Neuroscience Letters, Vol. 445, No. 2, 14.11.2008, p. 174-178.

Research output: Contribution to journalArticle

Chen, Shyan-Shiou ; Tu, Pei Chi ; Su, Tung Ping ; Hsieh, Jen Chuen ; Lin, Ying Chia ; Chen, Li Fen. / Impaired frontal synchronization of spontaneous magnetoencephalographic activity in patients with bipolar disorder. In: Neuroscience Letters. 2008 ; Vol. 445, No. 2. pp. 174-178.
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