Immunomagnetical reduction using high T c superconducting quantum interference device (SQUID)

J. J. Chieh, C. H. Chen, S. Y. Yang, H. E. Horng, H. C. Yang, Chin Yih Hong

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    In this work, we develop a platform for assaying biomolecules involving the measurement of alternating current ac magnetoreduction of magnetic reagent mixed with a detected sample. The magnetic reagent contains magnetic nanoparticles coated with a given kind of antibody, which associates with conjugated biomolecules. Then, the biomolecules can be quantitatively detected by measuring the ac magnetoreduction of magnetic reagent. To achieve hyper-high-sensitivity assay, a system utilizing a high-transition-temperature rf superconducting quantum interference device (SQUID) as a sensor to probe the magnetoreduction of reagent due to the association between biomolecules and magnetic nanoparticles. Examples to assay human CRP are given to demonstrate the validity of the assay platform, as well as the hyper-high sensitivity.

    Original languageEnglish
    Title of host publicationProceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009
    Pages364-365
    Number of pages2
    DOIs
    Publication statusPublished - 2009 Nov 18
    Event2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009 - Taichung, Taiwan
    Duration: 2009 Jun 222009 Jun 24

    Publication series

    NameProceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009

    Other

    Other2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009
    CountryTaiwan
    CityTaichung
    Period2009/06/222009/06/24

    Keywords

    • Ac magnetoreduction
    • Magnetic nanoparticles
    • SQUID

    ASJC Scopus subject areas

    • Information Systems
    • Biomedical Engineering
    • Health Informatics

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