Immunomagnetic reduction for fetal fibronectin detection a novel method to detect the preterm biomarker

Chen Yu Chen, Chia Chen Chang, Chun Yu, Shieh Yueh Yang, Chii Wann Lin

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Preterm birth is the main cause of perinatal morbidity and mortality throughout the world. Fetal fibronectin (fFN) is one type of glycoprotein detected in the interface of the choriodecidual junction. Preterm labor is related to the disruption of the choriodecidual junction and thus fFN releases in the ectocervix or posterior vaginal fornix. Quantization of fFN can assist the diagnosis and prevention of preterm birth. In this work, we developed an immunoassay, the immunomagnetic reduction (IMR), to quantitatively detect fFN. It was found that the low detection limit for fFN via IMR is less than 10 ng/ml, which is much lower than clinic criteria 50 ng/ml. In addition to the high sensitivity, IMR assay shows such merits as low cost and high reliability for detecting fFN.

    Original languageEnglish
    Pages (from-to)273-278
    Number of pages6
    JournalBiomedical Engineering - Applications, Basis and Communications
    Volume23
    Issue number4
    DOIs
    Publication statusPublished - 2011 Aug 1

    Keywords

    • Fetal fibronectin
    • Immunomagnetic reduction
    • Preterm birth

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering
    • Biomedical Engineering

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