Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry

J. J. Chieh; Shieh Yueh Yang; Herng Er Horng; C. Y. Yu; C. L. Lee; H. L. Wu; Chin Yih Hong; Hong Chang Yang

doi:10.1063/1.3340861

Immunomagnetic reduction assay using high-T_c superconducting-quantum-interference-device-based magnetosusceptometry

J. J. Chieh
, Shieh Yueh Yang
, Herng Er Horng^*
, C. Y. Yu
, C. L. Lee
, H. L. Wu
, Chin Yih Hong
, Hong Chang Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.

Original language	English
Article number	074903
Journal	Journal of Applied Physics
Volume	107
Issue number	7
DOIs	https://doi.org/10.1063/1.3340861
Publication status	Published - 2010 Apr 1

ASJC Scopus subject areas

General Physics and Astronomy

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10.1063/1.3340861

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title = "Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry",

abstract = "Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.",

author = "Chieh, \{J. J.\} and Yang, \{Shieh Yueh\} and Horng, \{Herng Er\} and Yu, \{C. Y.\} and Lee, \{C. L.\} and Wu, \{H. L.\} and Hong, \{Chin Yih\} and Yang, \{Hong Chang\}",

note = "Funding Information: This work is supported by National Science Council of Taiwan under Grant Nos. 98-2323-B-003-001-CC2, 98-2112-M-003-003, 98–221–E-003–001–MY2, and 98-2752-M-002-016-PAE, and Ministry of Economic Affairs under Grant Nos. 1Z970688 (SBIR) and S09800226-203 (JAID), and Department of Helath under Grant Nos. DOH98-TD-N-111-008 and 99G0012. ",

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AU - Lee, C. L.

AU - Wu, H. L.

AU - Hong, Chin Yih

AU - Yang, Hong Chang

N1 - Funding Information: This work is supported by National Science Council of Taiwan under Grant Nos. 98-2323-B-003-001-CC2, 98-2112-M-003-003, 98–221–E-003–001–MY2, and 98-2752-M-002-016-PAE, and Ministry of Economic Affairs under Grant Nos. 1Z970688 (SBIR) and S09800226-203 (JAID), and Department of Helath under Grant Nos. DOH98-TD-N-111-008 and 99G0012.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.

AB - Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.

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Immunomagnetic reduction assay using high-T_c superconducting-quantum-interference-device-based magnetosusceptometry

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