Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry

J. J. Chieh, Shieh Yueh Yang, Herng Er Horng*, C. Y. Yu, C. L. Lee, H. L. Wu, Chin Yih Hong, Hong Chang Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.

Original languageEnglish
Article number074903
JournalJournal of Applied Physics
Issue number7
Publication statusPublished - 2010 Apr 1

ASJC Scopus subject areas

  • General Physics and Astronomy


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