Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry

Jen-Je Chieh, Shieh-Yueh Yang, Herng-Er Horng, C. Y. Yu, C. L. Lee, H. L. Wu, Chin Yih Hong, Hong-Chang Yang

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.

    Original languageEnglish
    Article number074903
    JournalJournal of Applied Physics
    Volume107
    Issue number7
    DOIs
    Publication statusPublished - 2010 Apr 1

    Fingerprint

    interference
    magnetic signals
    sensitivity
    markers
    magnetometers
    marking
    nanoparticles
    scanning
    sensors

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

    Cite this

    Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry. / Chieh, Jen-Je; Yang, Shieh-Yueh; Horng, Herng-Er; Yu, C. Y.; Lee, C. L.; Wu, H. L.; Hong, Chin Yih; Yang, Hong-Chang.

    In: Journal of Applied Physics, Vol. 107, No. 7, 074903, 01.04.2010.

    Research output: Contribution to journalArticle

    Chieh, Jen-Je ; Yang, Shieh-Yueh ; Horng, Herng-Er ; Yu, C. Y. ; Lee, C. L. ; Wu, H. L. ; Hong, Chin Yih ; Yang, Hong-Chang. / Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry. In: Journal of Applied Physics. 2010 ; Vol. 107, No. 7.
    @article{3439945eabbc4991b49dcf468f60c592,
    title = "Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry",
    abstract = "Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.",
    author = "Jen-Je Chieh and Shieh-Yueh Yang and Herng-Er Horng and Yu, {C. Y.} and Lee, {C. L.} and Wu, {H. L.} and Hong, {Chin Yih} and Hong-Chang Yang",
    year = "2010",
    month = "4",
    day = "1",
    doi = "10.1063/1.3340861",
    language = "English",
    volume = "107",
    journal = "Journal of Applied Physics",
    issn = "0021-8979",
    publisher = "American Institute of Physics Publising LLC",
    number = "7",

    }

    TY - JOUR

    T1 - Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry

    AU - Chieh, Jen-Je

    AU - Yang, Shieh-Yueh

    AU - Horng, Herng-Er

    AU - Yu, C. Y.

    AU - Lee, C. L.

    AU - Wu, H. L.

    AU - Hong, Chin Yih

    AU - Yang, Hong-Chang

    PY - 2010/4/1

    Y1 - 2010/4/1

    N2 - Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.

    AB - Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated.

    UR - http://www.scopus.com/inward/record.url?scp=77951584701&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=77951584701&partnerID=8YFLogxK

    U2 - 10.1063/1.3340861

    DO - 10.1063/1.3340861

    M3 - Article

    AN - SCOPUS:77951584701

    VL - 107

    JO - Journal of Applied Physics

    JF - Journal of Applied Physics

    SN - 0021-8979

    IS - 7

    M1 - 074903

    ER -