Imaging of Magnetic Nanoparticles Using a Second Harmonic of Magnetization With DC Bias Field

Saburo Tanaka; Hayaki Murata; Tomoya Oishi; Yoshimi Hatsukade; Yi Zhang; Herng Er Horng; Shu Hsien Liao; Hong Chang Yang

doi:10.1109/TMAG.2014.2322375

Imaging of Magnetic Nanoparticles Using a Second Harmonic of Magnetization With DC Bias Field

Saburo Tanaka^*
, Hayaki Murata
, Tomoya Oishi
, Yoshimi Hatsukade
, Yi Zhang
, Herng Er Horng
, Shu Hsien Liao
, Hong Chang Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We have developed a method to improve the detection sensitivity for the magnetization M of magnetic nanoparticles (MNPs) using a high Tc superconducting quantum interference device magnetometer. The M response of MNP to an applied magnetic field H(M-H characteristics) can be divided into a linear region and a saturation region, which are separated at a transition point H_k. When applying an excitation ac magnetic field (H_ac) and an additional dc bias field H_dc = H_k, the second harmonic of M reaches a maximum due to the nonlinearity of its M - H characteristics. This harmonic is stronger than any other harmonics, including a third harmonic. The advantage of using the second harmonic response is that the response can be measured even in a small field H_ac. The M response of MNP was systematically analyzed and experimentally demonstrated. For conventional detection using a third harmonic, the amplitude of the H_ac must be larger than the threshold level, which is almost the same as H_k. Detection methods using a second harmonic can be applied to magnetic particle imaging. We finally demonstrate the construction of a 1-D image of two separated bottle-shaped MNP samples using the method with a lock-in amplifier.

Original language	English
Article number	6502504
Pages (from-to)	6502504
Number of pages	1
Journal	IEEE Transactions on Magnetics
Volume	51
Issue number	2
DOIs	https://doi.org/10.1109/TMAG.2014.2322375
Publication status	Published - 2015 Feb 1

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

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title = "Imaging of Magnetic Nanoparticles Using a Second Harmonic of Magnetization With DC Bias Field",

abstract = "We have developed a method to improve the detection sensitivity for the magnetization M of magnetic nanoparticles (MNPs) using a high Tc superconducting quantum interference device magnetometer. The M response of MNP to an applied magnetic field H(M-H characteristics) can be divided into a linear region and a saturation region, which are separated at a transition point Hk. When applying an excitation ac magnetic field (Hac) and an additional dc bias field Hdc = Hk, the second harmonic of M reaches a maximum due to the nonlinearity of its M - H characteristics. This harmonic is stronger than any other harmonics, including a third harmonic. The advantage of using the second harmonic response is that the response can be measured even in a small field Hac. The M response of MNP was systematically analyzed and experimentally demonstrated. For conventional detection using a third harmonic, the amplitude of the Hac must be larger than the threshold level, which is almost the same as Hk. Detection methods using a second harmonic can be applied to magnetic particle imaging. We finally demonstrate the construction of a 1-D image of two separated bottle-shaped MNP samples using the method with a lock-in amplifier.",

author = "Saburo Tanaka and Hayaki Murata and Tomoya Oishi and Yoshimi Hatsukade and Yi Zhang and Horng, \{Herng Er\} and Liao, \{Shu Hsien\} and Yang, \{Hong Chang\}",

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doi = "10.1109/TMAG.2014.2322375",

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AU - Tanaka, Saburo

AU - Murata, Hayaki

AU - Oishi, Tomoya

AU - Hatsukade, Yoshimi

AU - Zhang, Yi

AU - Horng, Herng Er

AU - Liao, Shu Hsien

AU - Yang, Hong Chang

PY - 2015/2/1

Y1 - 2015/2/1

N2 - We have developed a method to improve the detection sensitivity for the magnetization M of magnetic nanoparticles (MNPs) using a high Tc superconducting quantum interference device magnetometer. The M response of MNP to an applied magnetic field H(M-H characteristics) can be divided into a linear region and a saturation region, which are separated at a transition point Hk. When applying an excitation ac magnetic field (Hac) and an additional dc bias field Hdc = Hk, the second harmonic of M reaches a maximum due to the nonlinearity of its M - H characteristics. This harmonic is stronger than any other harmonics, including a third harmonic. The advantage of using the second harmonic response is that the response can be measured even in a small field Hac. The M response of MNP was systematically analyzed and experimentally demonstrated. For conventional detection using a third harmonic, the amplitude of the Hac must be larger than the threshold level, which is almost the same as Hk. Detection methods using a second harmonic can be applied to magnetic particle imaging. We finally demonstrate the construction of a 1-D image of two separated bottle-shaped MNP samples using the method with a lock-in amplifier.

AB - We have developed a method to improve the detection sensitivity for the magnetization M of magnetic nanoparticles (MNPs) using a high Tc superconducting quantum interference device magnetometer. The M response of MNP to an applied magnetic field H(M-H characteristics) can be divided into a linear region and a saturation region, which are separated at a transition point Hk. When applying an excitation ac magnetic field (Hac) and an additional dc bias field Hdc = Hk, the second harmonic of M reaches a maximum due to the nonlinearity of its M - H characteristics. This harmonic is stronger than any other harmonics, including a third harmonic. The advantage of using the second harmonic response is that the response can be measured even in a small field Hac. The M response of MNP was systematically analyzed and experimentally demonstrated. For conventional detection using a third harmonic, the amplitude of the Hac must be larger than the threshold level, which is almost the same as Hk. Detection methods using a second harmonic can be applied to magnetic particle imaging. We finally demonstrate the construction of a 1-D image of two separated bottle-shaped MNP samples using the method with a lock-in amplifier.

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Imaging of Magnetic Nanoparticles Using a Second Harmonic of Magnetization With DC Bias Field

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