TY - JOUR
T1 - Imaging of Magnetic Nanoparticles Using a Second Harmonic of Magnetization With DC Bias Field
AU - Tanaka, Saburo
AU - Murata, Hayaki
AU - Oishi, Tomoya
AU - Hatsukade, Yoshimi
AU - Zhang, Yi
AU - Horng, Herng Er
AU - Liao, Shu Hsien
AU - Yang, Hong Chang
N1 - Publisher Copyright:
© 1965-2012 IEEE.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - We have developed a method to improve the detection sensitivity for the magnetization M of magnetic nanoparticles (MNPs) using a high Tc superconducting quantum interference device magnetometer. The M response of MNP to an applied magnetic field H(M-H characteristics) can be divided into a linear region and a saturation region, which are separated at a transition point Hk. When applying an excitation ac magnetic field (Hac) and an additional dc bias field Hdc = Hk, the second harmonic of M reaches a maximum due to the nonlinearity of its M - H characteristics. This harmonic is stronger than any other harmonics, including a third harmonic. The advantage of using the second harmonic response is that the response can be measured even in a small field Hac. The M response of MNP was systematically analyzed and experimentally demonstrated. For conventional detection using a third harmonic, the amplitude of the Hac must be larger than the threshold level, which is almost the same as Hk. Detection methods using a second harmonic can be applied to magnetic particle imaging. We finally demonstrate the construction of a 1-D image of two separated bottle-shaped MNP samples using the method with a lock-in amplifier.
AB - We have developed a method to improve the detection sensitivity for the magnetization M of magnetic nanoparticles (MNPs) using a high Tc superconducting quantum interference device magnetometer. The M response of MNP to an applied magnetic field H(M-H characteristics) can be divided into a linear region and a saturation region, which are separated at a transition point Hk. When applying an excitation ac magnetic field (Hac) and an additional dc bias field Hdc = Hk, the second harmonic of M reaches a maximum due to the nonlinearity of its M - H characteristics. This harmonic is stronger than any other harmonics, including a third harmonic. The advantage of using the second harmonic response is that the response can be measured even in a small field Hac. The M response of MNP was systematically analyzed and experimentally demonstrated. For conventional detection using a third harmonic, the amplitude of the Hac must be larger than the threshold level, which is almost the same as Hk. Detection methods using a second harmonic can be applied to magnetic particle imaging. We finally demonstrate the construction of a 1-D image of two separated bottle-shaped MNP samples using the method with a lock-in amplifier.
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U2 - 10.1109/TMAG.2014.2322375
DO - 10.1109/TMAG.2014.2322375
M3 - Article
AN - SCOPUS:84930676432
SN - 0018-9464
VL - 51
SP - 6502504
JO - IEEE Transactions on Magnetics
JF - IEEE Transactions on Magnetics
IS - 2
M1 - 6502504
ER -