Identifying gene-disease associations using word proximity and similarity of Gene Ontology terms

Wen Juan Hou; Li Che Chen; Chieh Shiang Lu

doi:10.1109/BMEI.2011.6098702

Identifying gene-disease associations using word proximity and similarity of Gene Ontology terms

Wen Juan Hou^*
, Li Che Chen
, Chieh Shiang Lu

^*Corresponding author for this work

Department of Computer Science and Information Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Citations (Scopus)

Abstract

Associating genes with diseases is an active area of research because it is useful for helping human health with applications to clinical diagnosis and therapy. This paper proposes two methods to guide the associations between genes and diseases: (1) making use of the proximity relationship between genes and diseases and (2) utilizing GO terms shared by genes and diseases for similarity comparison. The experiments show that associations utilizing GO terms perform better than using word proximity. The results reveal that the GO terms act as a good gene-disease association feature.

Original language	English
Title of host publication	Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Pages	1748-1752
Number of pages	5
DOIs	https://doi.org/10.1109/BMEI.2011.6098702
Publication status	Published - 2011
Event	2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011 - Shanghai, China Duration: 2011 Oct 15 → 2011 Oct 17

Publication series

Name	Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Volume	4

Other

Other	2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Country/Territory	China
City	Shanghai
Period	2011/10/15 → 2011/10/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gene Ontology
bioinformatics
gene-disease association
text mining
word proximity relationship

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics
Health Information Management

Access to Document

10.1109/BMEI.2011.6098702

Cite this

Hou, W. J., Chen, L. C., & Lu, C. S. (2011). Identifying gene-disease associations using word proximity and similarity of Gene Ontology terms. In Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011 (pp. 1748-1752). Article 6098702 (Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011; Vol. 4). https://doi.org/10.1109/BMEI.2011.6098702

Identifying gene-disease associations using word proximity and similarity of Gene Ontology terms. / Hou, Wen Juan; Chen, Li Che; Lu, Chieh Shiang.
Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011. 2011. p. 1748-1752 6098702 (Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011; Vol. 4).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hou, WJ, Chen, LC & Lu, CS 2011, Identifying gene-disease associations using word proximity and similarity of Gene Ontology terms. in Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011., 6098702, Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011, vol. 4, pp. 1748-1752, 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011, Shanghai, China, 2011/10/15. https://doi.org/10.1109/BMEI.2011.6098702

Hou WJ, Chen LC, Lu CS. Identifying gene-disease associations using word proximity and similarity of Gene Ontology terms. In Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011. 2011. p. 1748-1752. 6098702. (Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011). doi: 10.1109/BMEI.2011.6098702

Hou, Wen Juan ; Chen, Li Che ; Lu, Chieh Shiang. / Identifying gene-disease associations using word proximity and similarity of Gene Ontology terms. Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011. 2011. pp. 1748-1752 (Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011).

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abstract = "Associating genes with diseases is an active area of research because it is useful for helping human health with applications to clinical diagnosis and therapy. This paper proposes two methods to guide the associations between genes and diseases: (1) making use of the proximity relationship between genes and diseases and (2) utilizing GO terms shared by genes and diseases for similarity comparison. The experiments show that associations utilizing GO terms perform better than using word proximity. The results reveal that the GO terms act as a good gene-disease association feature.",

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Identifying gene-disease associations using word proximity and similarity of Gene Ontology terms

Abstract

Publication series

Other

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this