Hypothermic neuroprotections in the brain of an echolocation bat, Hipposideros terasensis

Ching Lung Lin; Chun Jen Hsiao; Chih Hsiang Hsu; Sheue Er Wang; Philip H.S. Jen; Chung Hsin Wu

doi:10.1097/WNR.0000000000000856

Hypothermic neuroprotections in the brain of an echolocation bat, Hipposideros terasensis

Ching Lung Lin, Chun Jen Hsiao, Chih Hsiang Hsu, Sheue Er Wang, Philip H.S. Jen, Chung Hsin Wu

Department of Life Science

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The present study aimed to investigate how bats protect their brain in a hypothermic situation. Formosan leaf-nosed bats (Hipposideros terasensis) were used in this study and treated under three conditions: room temperature (25±1°C), low temperature (4±1°C), and hibernation. The reactive oxygen species (ROS) levels in the blood and apoptosis-related proteins in the brain tissue were assessed and then compared among those bats under three conditions. Our results showed that the blood ROS levels of bats treated under conditions of low temperature and hibernation were significantly reduced compared with bats treated under the condition of room temperature. Both immunohistochemistry and immunoblotting expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain tissue of bats treated under the condition of hibernation were significantly reduced compared with those bats treated under conditions of room temperature and low temperature. Thus, we suggested that bats can protect the brain in cold environment by reducing blood ROS levels and decreasing expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain. Possible protection mechanisms involved in hypothermic adaptations need to be further clarified.

Original language	English
Pages (from-to)	956-962
Number of pages	7
Journal	NeuroReport
Volume	28
Issue number	15
DOIs	https://doi.org/10.1097/WNR.0000000000000856
Publication status	Published - 2017

Keywords

apoptosis
bats
hibernation
hypothermic adaptation
reactive oxygen species

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1097/WNR.0000000000000856

Fingerprint Dive into the research topics of 'Hypothermic neuroprotections in the brain of an echolocation bat, Hipposideros terasensis'. Together they form a unique fingerprint.

Cite this

@article{b3ad9320d5944e24af1934643ebadde5,

title = "Hypothermic neuroprotections in the brain of an echolocation bat, Hipposideros terasensis",

abstract = "The present study aimed to investigate how bats protect their brain in a hypothermic situation. Formosan leaf-nosed bats (Hipposideros terasensis) were used in this study and treated under three conditions: room temperature (25±1°C), low temperature (4±1°C), and hibernation. The reactive oxygen species (ROS) levels in the blood and apoptosis-related proteins in the brain tissue were assessed and then compared among those bats under three conditions. Our results showed that the blood ROS levels of bats treated under conditions of low temperature and hibernation were significantly reduced compared with bats treated under the condition of room temperature. Both immunohistochemistry and immunoblotting expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain tissue of bats treated under the condition of hibernation were significantly reduced compared with those bats treated under conditions of room temperature and low temperature. Thus, we suggested that bats can protect the brain in cold environment by reducing blood ROS levels and decreasing expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain. Possible protection mechanisms involved in hypothermic adaptations need to be further clarified.",

keywords = "apoptosis, bats, hibernation, hypothermic adaptation, reactive oxygen species",

author = "Lin, {Ching Lung} and Hsiao, {Chun Jen} and Hsu, {Chih Hsiang} and Wang, {Sheue Er} and Jen, {Philip H.S.} and Wu, {Chung Hsin}",

note = "Funding Information: This research was supported by Top University Project of NTNU, the foundation of Ministry of Science and Technology of Taiwan (MOST 104-2320-B-003-004 and 105-2320-B-003-001).",

year = "2017",

doi = "10.1097/WNR.0000000000000856",

language = "English",

volume = "28",

pages = "956--962",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "15",

}

TY - JOUR

T1 - Hypothermic neuroprotections in the brain of an echolocation bat, Hipposideros terasensis

AU - Lin, Ching Lung

AU - Hsiao, Chun Jen

AU - Hsu, Chih Hsiang

AU - Wang, Sheue Er

AU - Jen, Philip H.S.

AU - Wu, Chung Hsin

N1 - Funding Information: This research was supported by Top University Project of NTNU, the foundation of Ministry of Science and Technology of Taiwan (MOST 104-2320-B-003-004 and 105-2320-B-003-001).

PY - 2017

Y1 - 2017

N2 - The present study aimed to investigate how bats protect their brain in a hypothermic situation. Formosan leaf-nosed bats (Hipposideros terasensis) were used in this study and treated under three conditions: room temperature (25±1°C), low temperature (4±1°C), and hibernation. The reactive oxygen species (ROS) levels in the blood and apoptosis-related proteins in the brain tissue were assessed and then compared among those bats under three conditions. Our results showed that the blood ROS levels of bats treated under conditions of low temperature and hibernation were significantly reduced compared with bats treated under the condition of room temperature. Both immunohistochemistry and immunoblotting expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain tissue of bats treated under the condition of hibernation were significantly reduced compared with those bats treated under conditions of room temperature and low temperature. Thus, we suggested that bats can protect the brain in cold environment by reducing blood ROS levels and decreasing expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain. Possible protection mechanisms involved in hypothermic adaptations need to be further clarified.

AB - The present study aimed to investigate how bats protect their brain in a hypothermic situation. Formosan leaf-nosed bats (Hipposideros terasensis) were used in this study and treated under three conditions: room temperature (25±1°C), low temperature (4±1°C), and hibernation. The reactive oxygen species (ROS) levels in the blood and apoptosis-related proteins in the brain tissue were assessed and then compared among those bats under three conditions. Our results showed that the blood ROS levels of bats treated under conditions of low temperature and hibernation were significantly reduced compared with bats treated under the condition of room temperature. Both immunohistochemistry and immunoblotting expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain tissue of bats treated under the condition of hibernation were significantly reduced compared with those bats treated under conditions of room temperature and low temperature. Thus, we suggested that bats can protect the brain in cold environment by reducing blood ROS levels and decreasing expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain. Possible protection mechanisms involved in hypothermic adaptations need to be further clarified.

KW - apoptosis

KW - bats

KW - hibernation

KW - hypothermic adaptation

KW - reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=85030839622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030839622&partnerID=8YFLogxK

U2 - 10.1097/WNR.0000000000000856

DO - 10.1097/WNR.0000000000000856

M3 - Article

AN - SCOPUS:85030839622

VL - 28

SP - 956

EP - 962

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 15

ER -