Abstract
The present study aimed to investigate how bats protect their brain in a hypothermic situation. Formosan leaf-nosed bats (Hipposideros terasensis) were used in this study and treated under three conditions: room temperature (25±1°C), low temperature (4±1°C), and hibernation. The reactive oxygen species (ROS) levels in the blood and apoptosis-related proteins in the brain tissue were assessed and then compared among those bats under three conditions. Our results showed that the blood ROS levels of bats treated under conditions of low temperature and hibernation were significantly reduced compared with bats treated under the condition of room temperature. Both immunohistochemistry and immunoblotting expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain tissue of bats treated under the condition of hibernation were significantly reduced compared with those bats treated under conditions of room temperature and low temperature. Thus, we suggested that bats can protect the brain in cold environment by reducing blood ROS levels and decreasing expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain. Possible protection mechanisms involved in hypothermic adaptations need to be further clarified.
| Original language | English |
|---|---|
| Pages (from-to) | 956-962 |
| Number of pages | 7 |
| Journal | NeuroReport |
| Volume | 28 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
Fingerprint
Keywords
- apoptosis
- bats
- hibernation
- hypothermic adaptation
- reactive oxygen species
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Hypothermic neuroprotections in the brain of an echolocation bat, Hipposideros terasensis. / Lin, Ching Lung; Hsiao, Chun Jen; Hsu, Chih Hsiang; Wang, Sheue Er; Jen, Philip H.S.; Wu, Chung-Hsin.
In: NeuroReport, Vol. 28, No. 15, 01.01.2017, p. 956-962.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypothermic neuroprotections in the brain of an echolocation bat, Hipposideros terasensis
AU - Lin, Ching Lung
AU - Hsiao, Chun Jen
AU - Hsu, Chih Hsiang
AU - Wang, Sheue Er
AU - Jen, Philip H.S.
AU - Wu, Chung-Hsin
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The present study aimed to investigate how bats protect their brain in a hypothermic situation. Formosan leaf-nosed bats (Hipposideros terasensis) were used in this study and treated under three conditions: room temperature (25±1°C), low temperature (4±1°C), and hibernation. The reactive oxygen species (ROS) levels in the blood and apoptosis-related proteins in the brain tissue were assessed and then compared among those bats under three conditions. Our results showed that the blood ROS levels of bats treated under conditions of low temperature and hibernation were significantly reduced compared with bats treated under the condition of room temperature. Both immunohistochemistry and immunoblotting expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain tissue of bats treated under the condition of hibernation were significantly reduced compared with those bats treated under conditions of room temperature and low temperature. Thus, we suggested that bats can protect the brain in cold environment by reducing blood ROS levels and decreasing expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain. Possible protection mechanisms involved in hypothermic adaptations need to be further clarified.
AB - The present study aimed to investigate how bats protect their brain in a hypothermic situation. Formosan leaf-nosed bats (Hipposideros terasensis) were used in this study and treated under three conditions: room temperature (25±1°C), low temperature (4±1°C), and hibernation. The reactive oxygen species (ROS) levels in the blood and apoptosis-related proteins in the brain tissue were assessed and then compared among those bats under three conditions. Our results showed that the blood ROS levels of bats treated under conditions of low temperature and hibernation were significantly reduced compared with bats treated under the condition of room temperature. Both immunohistochemistry and immunoblotting expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain tissue of bats treated under the condition of hibernation were significantly reduced compared with those bats treated under conditions of room temperature and low temperature. Thus, we suggested that bats can protect the brain in cold environment by reducing blood ROS levels and decreasing expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain. Possible protection mechanisms involved in hypothermic adaptations need to be further clarified.
KW - apoptosis
KW - bats
KW - hibernation
KW - hypothermic adaptation
KW - reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=85030839622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030839622&partnerID=8YFLogxK
U2 - 10.1097/WNR.0000000000000856
DO - 10.1097/WNR.0000000000000856
M3 - Article
AN - SCOPUS:85030839622
VL - 28
SP - 956
EP - 962
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 15
ER -