Hylocereus polyrhizus peel extract retards alcoholic liver disease progression by modulating oxidative stress and inflammatory responses in C57Bl/6 mice

Wan Ju Yeh, Chia Chun Tsai, Jung Ko, Hsin Yi Yang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Alcoholic liver disease (ALD) has become a health problem as alcohol consumption has increased annually. Hepatic lipid accumulation, oxidative stress, and inflammation are important factors in the progression of ALD. Red pitaya (Hylocereus polyrhizus (Weber) Britt. & Rose) peel is rich in polyphenols and betanins, which possess antioxidative and anti-inflammatory properties. Therefore, the aim of this study was to investigate the effects of red pitaya peel extract (PPE) on ALD and explore the associated mechanisms. C57BL/6 J mice were administered an ethanol liquid diet for 11 weeks with or without two different doses of PPE (500 and 1000 mg/kg BW). PPE treatment significantly ameliorated liver injury and hepatic fat accumulation, and it improved hepatic lipid metabolism via increases in AMPK and PPAR-a protein expression and a decrease in SREBP-1 expression. In addition, PPE inhibited CYP2E1 and Nrf2 protein expression, reduced endotoxin levels in the serum, and decreased TLR4 and MyD88 expression and inflammatory cytokine TNF-a and IL-1Β levels in the liver. In conclusion, these findings suggest that PPE may prevent the progression of ALD by modulating lipid metabolism and reducing oxidative stress and inflammatory responses.

Original languageEnglish
Article number3884
Pages (from-to)1-12
Number of pages12
JournalNutrients
Volume12
Issue number12
DOIs
Publication statusPublished - 2020 Dec

Keywords

  • Alcoholic liver disease
  • Fatty liver
  • Inflammation
  • Oxidative stress
  • Red pitaya

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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