Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl·LiCl

Wen-Wei Lin, Oliver Baron, Paul Knochel

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl·LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained.

Original languageEnglish
Pages (from-to)5673-5676
Number of pages4
JournalOrganic Letters
Volume8
Issue number24
DOIs
Publication statusPublished - 2006 Nov 23

Fingerprint

Bearings (structural)
Nitriles
nitriles
Benzene
Ketones
ketones
esters
Quenching
Esters
quenching
benzene
preparation
synthesis
benzophenone

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl·LiCl. / Lin, Wen-Wei; Baron, Oliver; Knochel, Paul.

In: Organic Letters, Vol. 8, No. 24, 23.11.2006, p. 5673-5676.

Research output: Contribution to journalArticle

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