Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl·LiCl

Wenwei Lin, Oliver Baron, Paul Knochel

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124 Citations (Scopus)


The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl·LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained.

Original languageEnglish
Pages (from-to)5673-5676
Number of pages4
JournalOrganic Letters
Issue number24
Publication statusPublished - 2006 Nov 23


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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