Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by a pyrrolidinyl-camphor-derived organocatalyst

Dhananjay R. Magar, Chihliang Chang, Ying Fang Ting, Kwunmin Chen

Research output: Contribution to journalArticle

31 Citations (Scopus)


Pyrrolidinyl-camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96%ee) under solvent-free reaction conditions at ambient temperature.

Original languageEnglish
Pages (from-to)2062-2066
Number of pages5
JournalEuropean Journal of Organic Chemistry
Issue number11
Publication statusPublished - 2010 Apr 1



  • Diesters
  • Enantioselectivity
  • Ketones
  • Lactones
  • Michael addition
  • Organocatalysis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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