Herbal therapies for type 2 diabetes mellitus: Chemistry, biology, and potential application of selected plants and compounds

Cicero L.T. Chang, Yenshou Lin, Arlene P. Bartolome, Yi Ching Chen, Shao Chih Chiu, Wen Chin Yang

Research output: Contribution to journalReview article

115 Citations (Scopus)

Abstract

Diabetes mellitus has been recognized since antiquity. It currently affects as many as 285 million people worldwide and results in heavy personal and national economic burdens. Considerable progress has been made in orthodox antidiabetic drugs. However, new remedies are still in great demand because of the limited efficacy and undesirable side effects of current orthodox drugs. Nature is an extraordinary source of antidiabetic medicines. To date, more than 1200 flowering plants have been claimed to have antidiabetic properties. Among them, one-third have been scientifically studied and documented in around 460 publications. In this review, we select and discuss blood glucose-lowering medicinal herbs that have the ability to modulate one or more of the pathways that regulate insulin resistance, β-cell function, GLP-1 homeostasis, and glucose (re)absorption. Emphasis is placed on phytochemistry, anti-diabetic bioactivities, and likely mechanism(s). Recent progress in the understanding of the biological actions, mechanisms, and therapeutic potential of compounds and extracts of plant origin in type 2 diabetes is summarized. This review provides a source of up-to-date information for further basic and clinical research into herbal therapy for type 2 diabetes. Emerging views on therapeutic strategies for type 2 diabetes are also discussed.

Original languageEnglish
Article number378657
JournalEvidence-based Complementary and Alternative Medicine
Volume2013
DOIs
Publication statusPublished - 2013 May 13

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Phytotherapy
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Glucagon-Like Peptide 1
Plant Extracts
Medicinal Plants
Insulin Resistance
Blood Glucose
Publications
Diabetes Mellitus
Homeostasis
Economics
Glucose
Therapeutics
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Herbal therapies for type 2 diabetes mellitus : Chemistry, biology, and potential application of selected plants and compounds. / Chang, Cicero L.T.; Lin, Yenshou; Bartolome, Arlene P.; Chen, Yi Ching; Chiu, Shao Chih; Yang, Wen Chin.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2013, 378657, 13.05.2013.

Research output: Contribution to journalReview article

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