Hepatocyte growth factor acts as a mitogen and chemoattractant for postnatal subventricular zone-olfactory bulb neurogenesis

Tsu-Wei Wang, Huailin Zhang, Margaret R. Gyetko, Jack M. Parent

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Neural progenitor cells persist throughout life in the forebrain subventricular zone (SVZ). They generate neuroblasts that migrate to the olfactory bulb and differentiate into interneurons, but mechanisms underlying these processes are poorly understood. Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic factor that influences cell motility, proliferation and morphogenesis in neural and non-neural tissues. HGF and its receptor, c-Met, are present in the rodent SVZ-olfactory bulb pathway. Using in vitro neurogenesis assays and in vivo studies of partially HGF-deficient mice, we find that HGF promotes SVZ cell proliferation and progenitor cell maintenance, while slowing differentiation and possibly altering cell fate choices. HGF also acts as a chemoattractant for SVZ neuroblasts in co-culture assays. Decreased HGF signaling induces ectopic SVZ neuroblast migration and alters the timing of migration to the olfactory bulb. These results suggest that HGF influences multiple steps in postnatal forebrain neurogenesis. HGF is a mitogen for SVZ neural progenitors, and regulates their differentiation and olfactory bulb migration.

Original languageEnglish
Pages (from-to)38-50
Number of pages13
JournalMolecular and Cellular Neuroscience
Volume48
Issue number1
DOIs
Publication statusPublished - 2011 Sep 1

Fingerprint

Hepatocyte Growth Factor
Lateral Ventricles
Olfactory Bulb
Chemotactic Factors
Neurogenesis
Mitogens
Prosencephalon
Stem Cells
Cell Proliferation
Proto-Oncogene Proteins c-met
Olfactory Pathways
Interneurons
Coculture Techniques
Morphogenesis
Cell Movement
Rodentia
Maintenance

Keywords

  • Hepatocyte growth factor
  • Neural stem cell
  • Neurogenesis
  • Neurosphere
  • Olfactory bulb
  • Subventricular zone

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Hepatocyte growth factor acts as a mitogen and chemoattractant for postnatal subventricular zone-olfactory bulb neurogenesis. / Wang, Tsu-Wei; Zhang, Huailin; Gyetko, Margaret R.; Parent, Jack M.

In: Molecular and Cellular Neuroscience, Vol. 48, No. 1, 01.09.2011, p. 38-50.

Research output: Contribution to journalArticle

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