Heat shock protein expression protects against death following exposure to heatstroke in rats

Yi Ling Yang, Kwok Tung Lu, Huey Jen Tsay, Chia Hsuan Lin, Mao Tsun Lin

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Rats 0, 16, or 48 h after heat shock (42°C core temperature for 15 min) or chemical stress (5 mg/kg sodium arsenfte, i.p.) were exposed to a high ambient temperature (43°C) to induce heatstroke onset. The moment in which the mean arterial pressure and cerebral blood flow began to decrease from their peak values was taken as the onset of heatstroke. Pdor heat shock or chemioal stress conferred significant protection against heatstroke-induced arterial hypotension, cerebral ischemia, cerebral neuronal damage and death, and correlated with expression of HSP72 in brain, heart, liver and kidney at 16 h. However, at 48 h, when HSP72 expression returned to basal values, the above responses that occurred after the onset of heatstroke of two groups (0 h group VS 48 h group) were indistinguishable. The data suggest that HSP72 presence increases survival in rat heatstroke by attenuating arterial hypotension, cerebral ischemia and neuronal damage.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalNeuroscience Letters
Volume252
Issue number1
DOIs
Publication statusPublished - 1998 Jul 27

Keywords

  • Cell death
  • Cerebral ischemia
  • Heatstroke
  • Survival

ASJC Scopus subject areas

  • Neuroscience(all)

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