Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia

H. C. Fung, C. M. Chen, Y. R. Wu, W. C. Hsu, L. S. Ro, J. C. Lin, K. H. Chang, H. K. Wang, S. J. Lin, H. Chan, Y. Y. Lin, S. L. Wei, Yu-Ying Hsu, Ji-Chuu Hwang, L. C. Tung, Guey-Jen Lee

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Abstract

This study was to determine whether polymorphisms of heat shock protein 70-1 (HSP70-1) and tumor necrosis factor α (TNF-α) are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). Using the criteria of the NINCDS-ADRDA and NINDS-AIREN, 125 AD patients, 57 VaD patients and 109 ethnically matched nondemented controls were enrolled. The HSP70-1 -110 A/C and TNF-α -1031 T/C, -863 C/A and -857 C/T polymorphisms were analyzed by means of genotype or haplotype association methods. None of the four genotypes examined showed a statistically significant difference in genotype distribution between the AD cases and controls. However, the HSP70-1 -110 CC genotype occurred more frequently among AD cases (p = 0.0821; odds ratio: 2.08; 95% confidence interval, CI: 0.92-4.98). The overall genotype distribution among the VaD cases tended to be different at the HSP70-1 -110 and TNF-α -1031 sites (p = 0.0604 and 0.0316, respectively). The HSP70-1 -110 CC genotype was more frequent (p = 0.0459), and the association of the -110 CC genotype with VaD was evident (p = 0.0207; odds ratio: 3.22; 95% CI: 1.20-8.87). The more frequent TNF-α -1031 TC genotype (p = 0.0614) was also evidently associated with VaD (p = 0.0209; odds ratio: 2.32; 95% CI: 1.14-4.78). Multivariate analysis demonstrated the synergistic effect of the HSP70-1 -110 CC and TNF-α -1031 TC/CC genotypes on VaD (p = 0.0091; odds ratio: 10.09; 95% CI: 2.01-75.97). Haplotype analysis among TNF-α -1031, -863, -857 sites revealed that -1031C-857C may act as a risk haplotype among VaD cases (p = 0.0132, odds ratio: 2.26; 95% CI: 1.19-4.33). Our results suggest a potential protective role for HSP70 in both VaD and AD, whereas TNF-α may act as a risk factor only for VaD, and not for AD.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume20
Issue number1
DOIs
Publication statusPublished - 2005 Jun 1

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Keywords

  • Dementia
  • Heat shock protein 70
  • Taiwanese
  • Tumor necrosis factor α

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Fung, H. C., Chen, C. M., Wu, Y. R., Hsu, W. C., Ro, L. S., Lin, J. C., Chang, K. H., Wang, H. K., Lin, S. J., Chan, H., Lin, Y. Y., Wei, S. L., Hsu, Y-Y., Hwang, J-C., Tung, L. C., & Lee, G-J. (2005). Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia. Dementia and Geriatric Cognitive Disorders, 20(1), 1-7. https://doi.org/10.1159/000085067