Abstract
A protocol for the N-bromosuccinimide (NBS)- and trichloroisocyanuric acid (TCCA)-mediated synthesis of novel 2-halomethylene-3-oxoketoximes via one-pot halogenation/oxidation of isoxazoline N-oxide derivatives is described here. The keto functionality of 3-ketoximes was selectively reduced by lithiumaluminum hydride to synthesize an unprecedented type of Baylis-Hillman oxime, which underwent N-O coupling to produce new isoxazoline N-oxide derivative.
Original language | English |
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Pages (from-to) | 8872-8879 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 78 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2013 Sep 6 |
ASJC Scopus subject areas
- Organic Chemistry