Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis, and reduced migration ability

Chien Chih Chiu, Po Len Liu, Kuang Jing Huang, Hui Min Wang, Kuo Feng Chang, Chon Kit Chou, Fang Rong Chang, Inn Wen Chong, Kang Fang, Jia Shing Chen, Hsueh Wei Chang, Yang Chang Wu

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61 Citations (Scopus)

Abstract

We evaluated the possible anticancer performance of a natural compound, goniothalamin (GTN), against human lung cancer using as a non-small cell lung cancer (NSCLC) cell line, H1299, as the model system. Cellular proliferation was significantly inhibited by GTN. Using an improved alkaline comet-nuclear extract (comet-NE) assay, GTN was found to induce a significant increase in the tail DNA. Wound healing and zymography assays showed that GTN attenuated cell migration and caused a reduction in the activity level of two major migration-associated matrix metalloproteinases, MMP-2 and MMP-9. It can be concluded that the DNA-damaging effect of GTN against lung cancer cells leads to growth inhibition as well as a depression in migration ability. Therefore, GTN has potential as a chemotherapeutic agent against lung cancer.

Original languageEnglish
Pages (from-to)4288-4293
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume59
Issue number8
DOIs
Publication statusPublished - 2011 Apr 27

Keywords

  • Goniothalamin
  • cell migration
  • comet assay
  • matrix metalloproteinase
  • non-small cell lung cancer

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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  • Cite this

    Chiu, C. C., Liu, P. L., Huang, K. J., Wang, H. M., Chang, K. F., Chou, C. K., Chang, F. R., Chong, I. W., Fang, K., Chen, J. S., Chang, H. W., & Wu, Y. C. (2011). Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis, and reduced migration ability. Journal of Agricultural and Food Chemistry, 59(8), 4288-4293. https://doi.org/10.1021/jf200566a