TY - JOUR
T1 - Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019
T2 - A systematic analysis for the Global Burden of Disease Study 2019
AU - GBD 2019 Allergic Disorders Collaborators
AU - Shin, Youn Ho
AU - Hwang, Jimin
AU - Kwon, Rosie
AU - Lee, Seung Won
AU - Kim, Min Seo
AU - Shin, Jae Il
AU - Yon, Dong Keon
AU - Abate, Yohannes Habtegiorgis
AU - Abbasi-Kangevari, Mohsen
AU - Abbasi-Kangevari, Zeinab
AU - Abdelmasseh, Michael
AU - Abdulah, Deldar Morad
AU - Aboagye, Richard Gyan
AU - Abolhassani, Hassan
AU - Abrams, Elissa M.
AU - Abtew, Yonas Derso
AU - Abu-Gharbieh, Eman
AU - Adane Adane, Denberu Eshetie
AU - Adane, Tigist Demssew
AU - Addo, Isaac Yeboah
AU - Adha, Rishan
AU - Adibi, Amin
AU - Sakilah Adnani, Qorinah Estiningtyas
AU - Agrawal, Anurag
AU - Ahmad, Sohail
AU - Ahmadi, Ali
AU - Ahmed, Ali
AU - Ahmed, Ayman
AU - Al-Azzam, Sayer
AU - Naji Alhalaiqa, Fadwa Alhalaiqa
AU - Alif, Sheikh Mohammad
AU - Alipour, Vahid
AU - Altaany, Zaid
AU - Altirkawi, Khalid A.
AU - Alvis-Guzman, Nelson
AU - Aly, Hany
AU - Ansar, Adnan
AU - Arulappan, Judie
AU - Asghari-Jafarabadi, Mohammad
AU - Ashraf, Tahira
AU - Athari, Seyyed Shamsadin
AU - Atlaw, Daniel
AU - Aujayeb, Avinash
AU - Azadnajafabad, Sina
AU - Babaei, Mahsa
AU - Babamohamadi, Hassan
AU - Badawi, Alaa
AU - Baghcheghi, Nayereh
AU - Bagherieh, Sara
AU - Li, Ming Chieh
N1 - Publisher Copyright:
© 2023 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
PY - 2023/8
Y1 - 2023/8
N2 - Background: Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and AD from 1990 to 2019 and analyze their associations with geographic, demographic, social, and clinical factors. Methods: Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019, we assessed the age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of both asthma and AD from 1990 to 2019, stratified by geographic region, age, sex, and socio-demographic index (SDI). DALYs were calculated as the sum of years lived with disability and years of life lost to premature mortality. Additionally, the disease burden of asthma attributable to high body mass index, occupational asthmagens, and smoking was described. Results: In 2019, there were a total of 262 million [95% uncertainty interval (UI): 224–309 million] cases of asthma and 171 million [95% UI: 165–178 million] total cases of AD globally; age-standardized prevalence rates were 3416 [95% UI: 2899–4066] and 2277 [95% UI: 2192–2369] per 100,000 population for asthma and AD, respectively, a 24.1% [95% UI: −27.2 to −20.8] decrease for asthma and a 4.3% [95% UI: 3.8–4.8] decrease for AD compared to baseline in 1990. Both asthma and AD had similar trends according to age, with age-specific prevalence rates peaking at age 5–9 years and rising again in adulthood. The prevalence and incidence of asthma and AD were both higher for individuals with higher SDI; however, mortality and DALYs rates of individuals with asthma had a reverse trend, with higher mortality and DALYs rates in those in the lower SDI quintiles. Of the three risk factors, high body mass index contributed to the highest DALYs and deaths due to asthma, accounting for a total of 3.65 million [95% UI: 2.14–5.60 million] asthma DALYs and 75,377 [95% UI: 40,615–122,841] asthma deaths. Conclusions: Asthma and AD continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age-standardized prevalence rates from 1990 to 2019. Although both are more frequent at younger ages and more prevalent in high-SDI countries, each condition has distinct temporal and regional characteristics. Understanding the temporospatial trends in the disease burden of asthma and AD could guide future policies and interventions to better manage these diseases worldwide and achieve equity in prevention, diagnosis, and treatment.
AB - Background: Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and AD from 1990 to 2019 and analyze their associations with geographic, demographic, social, and clinical factors. Methods: Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019, we assessed the age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of both asthma and AD from 1990 to 2019, stratified by geographic region, age, sex, and socio-demographic index (SDI). DALYs were calculated as the sum of years lived with disability and years of life lost to premature mortality. Additionally, the disease burden of asthma attributable to high body mass index, occupational asthmagens, and smoking was described. Results: In 2019, there were a total of 262 million [95% uncertainty interval (UI): 224–309 million] cases of asthma and 171 million [95% UI: 165–178 million] total cases of AD globally; age-standardized prevalence rates were 3416 [95% UI: 2899–4066] and 2277 [95% UI: 2192–2369] per 100,000 population for asthma and AD, respectively, a 24.1% [95% UI: −27.2 to −20.8] decrease for asthma and a 4.3% [95% UI: 3.8–4.8] decrease for AD compared to baseline in 1990. Both asthma and AD had similar trends according to age, with age-specific prevalence rates peaking at age 5–9 years and rising again in adulthood. The prevalence and incidence of asthma and AD were both higher for individuals with higher SDI; however, mortality and DALYs rates of individuals with asthma had a reverse trend, with higher mortality and DALYs rates in those in the lower SDI quintiles. Of the three risk factors, high body mass index contributed to the highest DALYs and deaths due to asthma, accounting for a total of 3.65 million [95% UI: 2.14–5.60 million] asthma DALYs and 75,377 [95% UI: 40,615–122,841] asthma deaths. Conclusions: Asthma and AD continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age-standardized prevalence rates from 1990 to 2019. Although both are more frequent at younger ages and more prevalent in high-SDI countries, each condition has distinct temporal and regional characteristics. Understanding the temporospatial trends in the disease burden of asthma and AD could guide future policies and interventions to better manage these diseases worldwide and achieve equity in prevention, diagnosis, and treatment.
KW - asthma
KW - atopic dermatitis
KW - disability-adjusted life years
KW - eczema
KW - epidemiology
KW - global burden
KW - mortality
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U2 - 10.1111/all.15807
DO - 10.1111/all.15807
M3 - Article
C2 - 37431853
AN - SCOPUS:85165169066
SN - 0105-4538
VL - 78
SP - 2232
EP - 2254
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 8
ER -