Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone

Ming Yang Li, Chia Ting Chang, Yueh Ting Han, Chien Po Liao, Jenn Yah Yu, Tsu Wei Wang

Research output: Contribution to journalArticle

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Abstract

Chinese herbal medicines (CHMs) have been used to treat human diseases for thousands of years. Among them, Ginkgo biloba is reported to be beneficial to the nervous system and a potential treatment of neurological disorders. Since the presence of adult neural stem cells (NSCs) brings hope that the brain may heal itself, whether the effect of Ginkgo biloba is on NSCs remains elusive. In this study, we found that Ginkgo biloba extract (GBE) and one of its main ingredients, ginkgolide B (GB) promoted cell cycle exit and neuronal differentiation in NSCs derived from the postnatal subventricular zone (SVZ) of the mouse lateral ventricle. Furthermore, the administration of GB increased the nuclear level of β-catenin and activated the canonical Wnt pathway. Knockdown of β-catenin blocked the neurogenic effect of GB, suggesting that GB promotes neuronal differentiation through the Wnt/β-catenin pathway. Thus, our data provide a potential mechanism underlying the therapeutic effect of GBE or GB on brain injuries and neurodegenerative disorders.

Original languageEnglish
Article number14947
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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ginkgolide B
Catenins
Wnt Signaling Pathway
Neural Stem Cells
Lateral Ventricles
Ginkgo biloba
Adult Stem Cells
Herbal Medicine
Brain Diseases
Therapeutic Uses
Nervous System Diseases
Neurodegenerative Diseases
Brain Injuries
Nervous System
Cell Cycle

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Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone. / Li, Ming Yang; Chang, Chia Ting; Han, Yueh Ting; Liao, Chien Po; Yu, Jenn Yah; Wang, Tsu Wei.

In: Scientific Reports, Vol. 8, No. 1, 14947, 01.12.2018.

Research output: Contribution to journalArticle

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AU - Liao, Chien Po

AU - Yu, Jenn Yah

AU - Wang, Tsu Wei

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