Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Han Lin Chiang; Guey Jen Lee-Chen; Chiung Mei Chen; Yi Chun Chen; Chei Mei Lee; Ming Hui Liao; Yih Ru Wu

doi:10.1016/j.parkreldis.2011.12.014

Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Han Lin Chiang, Guey Jen Lee-Chen, Chiung Mei Chen, Yi Chun Chen, Chei Mei Lee, Ming Hui Liao, Yih Ru Wu^*

^*Corresponding author for this work

Department of Life Science

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

Original language	English
Pages (from-to)	391-393
Number of pages	3
Journal	Parkinsonism and Related Disorders
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.parkreldis.2011.12.014
Publication status	Published - 2012 May

Keywords

Disease association
HLA
Parkinson's disease
Polymorphism

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2011.12.014

Cite this

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title = "Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease",

abstract = "Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.",

keywords = "Disease association, HLA, Parkinson's disease, Polymorphism",

author = "Chiang, {Han Lin} and Lee-Chen, {Guey Jen} and Chen, {Chiung Mei} and Chen, {Yi Chun} and Lee, {Chei Mei} and Liao, {Ming Hui} and Wu, {Yih Ru}",

note = "Funding Information: This work was supported by grant NSC98-2628-B-182A-001-MY3 from the National Science Council, Executive Yuan and grant CMRPG391181 and CMRPG3A0131 from Chang–Gung Memorial Hospital . We also thank the patients and controls for participating in this study. All authors have no conflict of interest to declare. ",

year = "2012",

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doi = "10.1016/j.parkreldis.2011.12.014",

language = "English",

volume = "18",

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AU - Chiang, Han Lin

AU - Lee-Chen, Guey Jen

AU - Chen, Chiung Mei

AU - Chen, Yi Chun

AU - Lee, Chei Mei

AU - Liao, Ming Hui

AU - Wu, Yih Ru

N1 - Funding Information: This work was supported by grant NSC98-2628-B-182A-001-MY3 from the National Science Council, Executive Yuan and grant CMRPG391181 and CMRPG3A0131 from Chang–Gung Memorial Hospital . We also thank the patients and controls for participating in this study. All authors have no conflict of interest to declare.

PY - 2012/5

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N2 - Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

AB - Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

KW - Disease association

KW - HLA

KW - Parkinson's disease

KW - Polymorphism

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Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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